Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Grm3. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Grm3
  • participates in the following biological processes:
    • adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway ^[1]
  • performs the following molecular functions:
    • calcium channel regulator activity ^[1]
    • group II metabotropic glutamate receptor activity ^[1]
  • is located in the following cellular components:
    • axon ^[4]
    • dendritic spine ^[4]
    • neuron projection ^[2]
    • plasma membrane ^[4]
    • postsynaptic density ^[3]
    • postsynaptic membrane ^[4]
    • presynaptic membrane ^[4]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Grm3:
  • participates in the following biological processes:
    • regulation of synaptic transmission
  • performs the following molecular functions:
    • group II metabotropic glutamate receptor activity

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Summary text based on GO annotations supported by structural data

• Grm3 encodes a protein or proteins that contain the following InterPro domains: Extracellular ligand-binding receptor, GPCR, family 3, GPCR, family 3, C-terminal, GPCR, family 3, conserved site, GPCR, family 3, metabotropic glutamate receptor, GPCR, family 3, metabotropic glutamate receptor 3, GPCR, family 3, nine cysteines domain, indicating that the gene product:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
  • performs the following molecular functions:
    • G-protein coupled receptor activity
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Grm3 indicates that it:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Chavis P et al. (1994) The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells. J Neurosci, 14:7067-76. (PubMed:7965099)
2. Fukami S et al. (2002) Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Neurosci Res, 43:39-56. (PubMed:12074840)
3. Nakamura M et al. (2004) Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain. Eur J Neurosci, 20:2929-44. (PubMed:15579147)
4. Tamaru Y et al. (2001) Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites. Neuroscience, 106:481-503. (PubMed:11591452)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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