Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Grm1. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Grm1
  • participates in the following biological processes:
    • activation of MAPK activity ^[2]
    • activation of MAPKK activity ^[2]
    • regulation of MAPK cascade ^[2]
    • regulation of sensory perception of pain ^[2]
  • is located in the following cellular components:
    • dendrite ^[1]
    • neuron projection ^[5]
    • nucleus ^[4]
    • postsynaptic density ^[4]
• The gene product of Grm1 has been shown to bind to the gene products of Homer1, Homer2, Homer3, Itpr1. ^{[3, 4, 7]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Grm1
  • participates in the following biological processes:
    • cellular response to electrical stimulus ^[6]
    • locomotory behavior ^[1]
    • sensory perception of pain ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Grm1:
  • participates in the following biological processes:
    • calcium-mediated signaling
    • regulation of synaptic transmission, glutamatergic
  • performs the following molecular functions:
    • estrogen receptor binding
  • is located in the following cellular components:
    • axon
    • dendritic spine
    • postsynaptic density
    • presynaptic membrane

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Summary text based on GO annotations supported by structural data

• Grm1 encodes a protein or proteins that contain the following InterPro domains: Extracellular ligand-binding receptor, GPCR, family 3, GPCR, family 3, C-terminal, GPCR, family 3, conserved site, GPCR, family 3, metabotropic glutamate receptor, GPCR, family 3, metabotropic glutamate receptor 1, GPCR, family 3, nine cysteines domain, Metabotropic glutamate receptor, Homer-binding domain, indicating that the gene product:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
  • performs the following molecular functions:
    • G-protein coupled receptor activity
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Grm1 indicates that it:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane
    • plasma membrane

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References

1. Ichise T et al. (2000) mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. Science, 288:1832-5. (PubMed:10846166)
2. Karim F et al. (2001) Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice. J Neurosci, 21:3771-9. (PubMed:11356865)
3. Mizutani A et al. (2008) Phosphorylation of Homer3 by calcium/calmodulin-dependent kinase II regulates a coupling state of its target molecules in Purkinje cells. J Neurosci, 28:5369-82. (PubMed:18480293)
4. Nakamura M et al. (2004) Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain. Eur J Neurosci, 20:2929-44. (PubMed:15579147)
5. Verpelli C et al. (2011) Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J Biol Chem, 286:34839-50. (PubMed:21795692)
6. Won J et al. (2011) Mouse model resources for vision research. J Ophthalmol, 2011:391384. (PubMed:21052544)
7. Xiao B et al. (1998) Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron, 21:707-16. (PubMed:9808458)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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