About   Help   FAQ
Gene Ontology Classifications
Symbol
Name
ID
Cartpt
CART prepropeptide
MGI:1351330

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cartpt. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


This gene encodes a preproprotein that is processed into multiple biologically active small secreted peptides. Expression of this gene is regulated by cocaine and other drugs, and is associated with feeding/appetite and stress response. Alternatively spliced transcript variants have been observed encoding different protein isoforms, each of which are subsequently processed into CART I and CART II mature peptides. [provided by RefSeq, Oct 2012]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
References
  1. Ahn JD et al. (2006) Cart overexpression is the only identifiable cause of high bone mass in melanocortin 4 receptor deficiency. Endocrinology, 147:3196-202. (PubMed:16614075)
  2. Elefteriou F et al. (2005) Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature, 434:514-20. (PubMed:15724149)
  3. Kristensen P et al. (1998) Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature, 393:72-6. (PubMed:9590691)
  4. Lakatos A et al. (2005) Cocaine- and amphetamine-regulated transcript (CART) peptide activates the extracellular signal-regulated kinase (ERK) pathway in AtT20 cells via putative G-protein coupled receptors. Neurosci Lett, 384:198-202. (PubMed:15908120)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/18/2014
MGI 5.20
The Jackson Laboratory