Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Tlx2. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of an orphan homeobox-containing transcription factor family. Studies of the mouse ortholog have shown that the encoded protein is crucial for the development of the enteric nervous system; in humans, loss-of-function may play a role in tumorigenesis of gastrointestinal stromal tumors. [provided by RefSeq, May 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Tlx2
  • participates in the following biological processes:
    • negative regulation of dendrite morphogenesis ^[2]
  • is located in the following cellular components:
    • cytoplasm ^[2]
    • nucleus ^[2]
• The gene product of Tlx2 has been shown to bind to the gene products of Ywhah. ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Tlx2
  • participates in the following biological processes:
    • enteric nervous system development ^[1]
    • mesoderm formation ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Tlx2:
  • participates in the following biological processes:
    • regulation of transcription from RNA polymerase II promoter
  • performs the following molecular functions:
    • DNA binding
    • sequence-specific DNA binding transcription factor activity
  • is located in the following cellular components:
    • nucleus

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Summary text based on GO annotations supported by structural data

• Tlx2 encodes a protein or proteins that contain the following InterPro domains: Homeobox, conserved site, Homeodomain, Homeodomain, metazoa, Homeodomain-like, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
  • performs the following molecular functions:
    • sequence-specific DNA binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Tlx2 indicates that it:
  • participates in the following biological processes:
    • multicellular organismal development
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent

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References

1. Hatano M et al. (1997) A novel pathogenesis of megacolon in Ncx/Hox11L.1 deficient mice. J Clin Invest, 100:795-801. (PubMed:9259577)
2. Tang SJ et al. (1998) Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins. J Biol Chem, 273:25356-63. (PubMed:9738002)
3. Tang SJ et al. (1998) The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development. Development, 125:1877-87. (PubMed:9550720)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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