Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Sec23b. (This text reflects annotations as of Thursday, January 16, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Sec23b
  • is located in the following cellular components:
    • perinuclear region of cytoplasm ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Sec23b:
  • is located in the following cellular components:
    • intracellular membrane-bounded organelle

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Summary text based on GO annotations supported by structural data

• Sec23b encodes a protein or proteins that contain the following InterPro domains: Gelsolin domain, Sec23/Sec24 beta-sandwich, Sec23/Sec24, helical domain, Sec23/Sec24, trunk domain, von Willebrand factor, type A, Zinc finger, Sec23/Sec24-type, indicating that the gene product:
  • participates in the following biological processes:
    • ER to Golgi vesicle-mediated transport
    • intracellular protein transport
  • performs the following molecular functions:
    • zinc ion binding
  • is located in the following cellular components:
    • COPII vesicle coat

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Sec23b indicates that it:
  • participates in the following biological processes:
    • protein transport
    • transport
    • vesicle-mediated transport
  • is located in the following cellular components:
    • endoplasmic reticulum
    • Golgi apparatus
    • membrane

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References

1. Merte J et al. (2010) Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure. Nat Cell Biol, 12:41-6; sup pp 1-8. (PubMed:19966784)
2. Zhang J et al. (2005) Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are potential interaction partners of testicular germ cell-specific protein GGN1. FEBS Lett, 579:559-66. (PubMed:15642376)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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