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Gene Ontology Classifications
Symbol
Name
ID
Ndufb11
NADH:ubiquinone oxidoreductase subunit B11
MGI:1349919

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Summary from NCBI RefSeq

This genomic region represents the regulatory region that exists upstream of the mouse alpha-globin gene cluster. It is orthologous to the human alpha-globin locus control region (LCR), which regulates developmental stage- and erythroid lineage-specific expression of the embryonic and adult alpha-globin genes. This region overlaps the Nprl3 (nitrogen permease regulator-like 3) gene, which is transcribed in the opposite orientation compared to the downstream alpha-globin genes, and it also overlaps the 3' end of the Mpg (N-methylpurine-DNA glycosylase) gene. Like the human ortholog, this mouse region is characterized by several DNase I hypersensitive sites (HSs), including the conserved erythroid-specific sites HS-8, HS-21, HS-26 and HS-31. Mouse HS-26 is orthologous to human HS-40, which is the major regulatory element in human. However, unlike human HS-40, mouse HS-26 has relatively weak enhancer activity and does not have LCR activity, suggesting that additional cis-acting elements are necessary for complete developmental regulation of the alpha-globin genes in mice. Five enhancer-like elements, R1, R2, R3, Rm and R4, which correlate with the HSs and/or ATAC-seq accessible sites, are located in this region. Together they constitute a super-enhancer, where each constituent enhancer acts in an additive manner to regulate developmental expression of the alpha-globin genes. Similar to the human counterpart, this mouse upstream regulatory region forms an active chromatin hub based on observed looping interactions with the active alpha-globin genes. [provided by RefSeq, May 2017]



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Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory