Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables ISG15 activating enzyme activity. Acts upstream of or within ISG15-protein conjugation and modification-dependent protein catabolic process. Predicted to be active in cytoplasm. Is expressed in liver lobe and thymus primordium. Orthologous to human UBA7 (ubiquitin like modifier activating enzyme 7).