Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear estrogen receptor binding activity. Acts upstream of or within several processes, including positive regulation of gonadotropin secretion; regulation of transcription by RNA polymerase II; and reproductive structure development. Located in nucleus. Is expressed in several structures, including adenohypophysis; branchial arch; eye; future pituitary; and genitourinary system. Used to study blepharophimosis, ptosis, and epicanthus inversus syndrome. Human ortholog(s) of this gene implicated in blepharophimosis, ptosis, and epicanthus inversus syndrome; lung non-small cell carcinoma; and primary ovarian insufficiency 3. Orthologous to human FOXL2 (forkhead box L2).