Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Figla. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida. Mutations in this gene cause premature ovarian failure type 6. [provided by RefSeq, Sep 2009]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Figla:
  • performs the following molecular functions:
    • sequence-specific DNA binding
    • transcription factor binding
  • is located in the following cellular components:
    • transcription factor complex

---

Summary text based on GO annotations supported by structural data

• Figla encodes a protein or proteins that contain the following InterPro domains: Helix-loop-helix domain, indicating that the gene product:
  • performs the following molecular functions:
    • protein dimerization activity

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Figla indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • multicellular organismal development
    • oogenesis
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • DNA binding
  • is located in the following cellular components:
    • nucleus

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---