Automated description from the Alliance of Genome Resources
Exhibits DNA binding activity; FAD binding activity; and NAD(P)H oxidase activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; neuron apoptotic process; and regulation of apoptotic DNA fragmentation. Localizes to the cytosol; mitochondrion; and nucleus. Used to study mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked recessive 4; X-linked nonsyndromic deafness; and combined oxidative phosphorylation deficiency. Is expressed in several structures, including early embryo and retina. Orthologous to human AIFM1 (apoptosis inducing factor mitochondria associated 1).