Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits Wnt-protein binding activity; frizzled binding activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including cell surface receptor signaling pathway; embryonic morphogenesis; and regulation of canonical Wnt signaling pathway. Predicted to localize to several cellular components, including dendrite; microtubule; and neuronal cell body. Is expressed in several structures, including embryo mesenchyme; genitourinary system; jaw; neural ectoderm; and sensory organ. Used to study autosomal recessive Robinow syndrome. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome; brachydactyly type B1; and cleft palate. Orthologous to human ROR2 (receptor tyrosine kinase like orphan receptor 2).