Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Foxm1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Foxm1
  • participates in the following biological processes:
    • positive regulation of transcription from RNA polymerase II promoter ^{[1, 4]}
  • performs the following molecular functions:
    • transcription regulatory region DNA binding ^[4]
  • is located in the following cellular components:
    • nucleus ^[4]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Foxm1
  • participates in the following biological processes:
    • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ^[5]
    • liver development ^[2]
    • positive regulation of cell proliferation ^[1]
    • positive regulation of double-strand break repair ^[5]
    • positive regulation of transcription, DNA-dependent ^[5]
    • regulation of cell proliferation ^[2]
    • vasculogenesis ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Foxm1:
  • participates in the following biological processes:
    • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
    • embryo development
    • G2/M transition of mitotic cell cycle
    • negative regulation of cell aging
    • negative regulation of stress-activated MAPK cascade
    • negative regulation of transcription from RNA polymerase II promoter
    • negative regulation of transcription, DNA-dependent
    • pattern specification process
    • positive regulation of cell proliferation
    • positive regulation of double-strand break repair
    • positive regulation of transcription from RNA polymerase II promoter
    • positive regulation of transcription, DNA-dependent
    • regulation of cell cycle arrest
    • regulation of Ras protein signal transduction
    • regulation of reactive oxygen species metabolic process
    • regulation of sequence-specific DNA binding transcription factor activity
    • regulation of transcription, DNA-dependent
    • tissue development
    • transcription from RNA polymerase II promoter
  • performs the following molecular functions:
    • DNA binding
    • DNA binding, bending
    • double-stranded DNA binding
    • protein domain specific binding
    • protein kinase binding
    • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
    • sequence-specific DNA binding
    • sequence-specific DNA binding transcription factor activity
    • transcription factor binding
  • is located in the following cellular components:
    • cytoplasm
    • nucleus
    • transcription factor complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Foxm1 indicates that it:
  • participates in the following biological processes:
    • cell cycle
    • DNA repair
    • response to DNA damage stimulus
    • transcription, DNA-dependent

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References

1. Kim IM et al. (2005) The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature. J Biol Chem, 280:22278-86. (PubMed:15817462)
2. Krupczak-Hollis K et al. (2004) The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis. Dev Biol, 276:74-88. (PubMed:15531365)
3. Luscher-Firzlaff JM et al. (1999) Interaction of the fork head domain transcription factor MPP2 with the human papilloma virus 16 E7 protein: enhancement of transformation and transactivation. Oncogene, 18:5620-30. (PubMed:10523841)
4. Malin D et al. (2007) Forkhead box F1 is essential for migration of mesenchymal cells and directly induces integrin-beta3 expression. Mol Cell Biol, 27:2486-98. (PubMed:17261592)
5. Tan Y et al. (2007) Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes. Mol Cell Biol, 27:1007-16. (PubMed:17101782)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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