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Gene Ontology Classifications
forkhead box C1

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GO curators for mouse genes have assigned the following annotations to the gene product of Foxc1. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of June 26, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
  1. Breen M et al. (1973) Acidic glycosaminoglycans in developing sterno-costal cartilage of the hydrocephalic (ch+-ch+) mouse. Biochim Biophys Acta, 304:828-36. (PubMed:4269479)
  2. Green MC. (1970) The developmental effects of congenital hydrocephalus (ch) in the mouse. Dev Biol, 23:585-608. (PubMed:5500588)
  3. Gruneberg H. (1953) Genetical studies on the skeleton of the mouse. VII. Congenital hydrocephalus J Genet, 51:327-58.
  4. Gruneberg H et al. (1974) A re-examination of two skeletal mutants of the mouse, vestigial-tail (vt) and congenital hydrocephalus (ch). J Embryol Exp Morphol, 31:207-22. (PubMed:4819561)
  5. Hayashi H et al. (2008) The Foxc2 transcription factor regulates angiogenesis via induction of integrin beta3 expression. J Biol Chem, 283:23791-800. (PubMed:18579532)
  6. Hong HK et al. (1999) Pleiotropic skeletal and ocular phenotypes of the mouse mutation congenital hydrocephalus (ch/Mf1) arise from a winged helix/forkhead transcriptionfactor gene. Hum Mol Genet, 8:625-37. (PubMed:10072431)
  7. Kidson SH et al. (1999) The forkhead/winged-helix gene, Mf1, is necessary for the normal development of the cornea and formation of the anterior chamber in the mouse eye. Dev Biol, 211:306-22. (PubMed:10395790)
  8. Kume T et al. (1998) The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus. Cell, 93:985-96. (PubMed:9635428)
  9. Kume T et al. (2000) Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract. Development, 127:1387-95. (PubMed:10704385)
  10. Kume T et al. (2001) The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. Genes Dev, 15:2470-82. (PubMed:11562355)
  11. Mattiske D et al. (2006) The role of the forkhead transcription factor, Foxc1, in the development of the mouse lacrimal gland. Dev Dyn, 235:1074-80. (PubMed:16470615)
  12. Mattiske D et al. (2006) The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development. Dev Biol, 290:447-58. (PubMed:16412416)
  13. Omatsu Y et al. (2014) Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation. Nature, 508:536-40. (PubMed:24590069)
  14. Raimondi AJ et al. (1973) The pathophysiology and morphology of murine hydrocephalus in Hy-3 and Ch mutants. Surg Neurol, 1:50-5. (PubMed:4784576)
  15. Rice R et al. (2003) Progression of calvarial bone development requires Foxc1 regulation of Msx2 and Alx4. Dev Biol, 262:75-87. (PubMed:14512019)
  16. Seo S et al. (2012) Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth. Proc Natl Acad Sci U S A, 109:2015-20. (PubMed:22171010)
  17. Seo S et al. (2006) The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development. Dev Biol, 294:458-70. (PubMed:16678147)
  18. Seo S et al. (2006) Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract. Dev Biol, 296:421-36. (PubMed:16839542)
  19. Smith RS et al. (2000) Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development. Hum Mol Genet, 9:1021-32. (PubMed:10767326)
  20. Winnier GE et al. (1999) Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles. Dev Biol, 213:418-31. (PubMed:10479458)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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