Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; R-SMAD binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including heart morphogenesis; regulation of transcription by RNA polymerase II; and transforming growth factor beta receptor signaling pathway. Acts upstream of or within axial mesoderm development; regionalization; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of activin responsive factor complex. Is expressed in several structures, including early conceptus; embryo mesoderm; lung; ovary; and ureter. Used to study agnathia-otocephaly complex and visceral heterotaxy. Orthologous to human FOXH1 (forkhead box H1).