Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Adamts2. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of May 22, 2006. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene excises the N-propeptide of type I, type II and type V procollagens. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Adamts2
  • participates in the following biological processes:
    • metabolic process ^[1]
  • performs the following molecular functions:
    • peptidase activity ^[1]
  • is located in the following cellular components:
    • extracellular matrix ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Adamts2
  • participates in the following biological processes:
    • collagen fibril organization ^[1]
    • lung development ^[1]
    • protein processing ^[1]
    • skin development ^[2]
    • spermatogenesis ^[2]

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Summary text based on GO annotations supported by structural data

• Adamts2 encodes a protein or proteins that contain the following InterPro domains: ADAM-TS Spacer 1, Metallopeptidase, catalytic domain, Peptidase M12B, ADAM-TS, Peptidase M12B, ADAM-TS2, Peptidase M12B, ADAM/reprolysin, Peptidase M12B, propeptide, PLAC, Thrombospondin, type 1 repeat, indicating that the gene product:
  • participates in the following biological processes:
    • proteolysis
  • performs the following molecular functions:
    • metalloendopeptidase activity
    • metallopeptidase activity
    • zinc ion binding
  • is located in the following cellular components:
    • proteinaceous extracellular matrix

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Adamts2 indicates that it:
  • participates in the following biological processes:
    • collagen catabolic process
    • integrin-mediated signaling pathway
    • proteolysis
  • performs the following molecular functions:
    • hydrolase activity
    • metal ion binding
    • metallopeptidase activity
  • is located in the following cellular components:
    • extracellular region
    • proteinaceous extracellular matrix

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References

1. Le Goff C et al. (2006) Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis. Development, 133:1587-96. (PubMed:16556917)
2. Li SW et al. (2001) Transgenic mice with inactive alleles for procollagen N-proteinase (ADAMTS-2) develop fragile skin and male sterility. Biochem J, 355:271-8. (PubMed:11284712)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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