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Gene Ontology Classifications
Symbol
Name
ID
Slc27a4
solute carrier family 27 (fatty acid transporter), member 4
MGI:1347347

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Slc27a4. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of October 6, 2009. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome. [provided by RefSeq, Apr 2010]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. DiRusso CC et al. (2008) Functional domains of the fatty acid transport proteins: studies using protein chimeras. Biochim Biophys Acta, 1781:135-43. (PubMed:18258213)
  2. Gimeno RE et al. (2003) Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality. J Biol Chem, 278:49512-6. (PubMed:14512415)
  3. Hall AM et al. (2005) Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice. J Biol Chem, 280:11948-54. (PubMed:15653672)
  4. Herrmann T et al. (2001) Mouse fatty acid transport protein 4 (FATP4): characterization of the gene and functional assessment as a very long chain acyl-CoA synthetase. Gene, 270:31-40. (PubMed:11404000)
  5. Herrmann T et al. (2005) Disturbed epidermal structure in mice with temporally controlled fatp4 deficiency. J Invest Dermatol, 125:1228-35. (PubMed:16354193)
  6. Herrmann T et al. (2003) Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy. J Cell Biol, 161:1105-15. (PubMed:12821645)
  7. Jia Z et al. (2007) Fatty acid transport protein 4 is the principal very long chain fatty acyl-CoA synthetase in skin fibroblasts. J Biol Chem, 282:20573-83. (PubMed:17522045)
  8. Milger K et al. (2006) Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4. J Cell Sci, 119:4678-88. (PubMed:17062637)
  9. Moulson CL et al. (2007) Keratinocyte-specific expression of fatty acid transport protein 4 rescues the wrinkle-free phenotype in Slc27a4/Fatp4 mutant mice. J Biol Chem, 282:15912-20. (PubMed:17401141)
  10. Pohl J et al. (2005) FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts. Mol Biol Cell, 16:24-31. (PubMed:15496455)
  11. Shim J et al. (2009) Fatty acid transport protein 4 is dispensable for intestinal lipid absorption in mice. J Lipid Res, 50:491-500. (PubMed:18843142)
  12. Stahl A et al. (1999) Identification of the major intestinal fatty acid transport protein. Mol Cell, 4:299-308. (PubMed:10518211)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory