About   Help   FAQ
Gene Ontology Classifications
Symbol
Name
ID
Axl
AXL receptor tyrosine kinase
MGI:1347244

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Axl. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of November 12, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Angelillo-Scherrer A et al. (2008) Role of Gas6 in erythropoiesis and anemia in mice. J Clin Invest, 118:583-96. (PubMed:18188450)
  2. Angelillo-Scherrer A et al. (2005) Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. J Clin Invest, 115:237-46. (PubMed:15650770)
  3. Bellosta P et al. (1997) Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation. Oncogene, 15:2387-97. (PubMed:9395235)
  4. Caraux A et al. (2006) Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases. Nat Immunol, 7:747-54. (PubMed:16751775)
  5. Chen Y et al. (2009) Functions of TAM RTKs in regulating spermatogenesis and male fertility in mice. Reproduction, 138:655-66. (PubMed:19602523)
  6. Hoehn HJ et al. (2008) Axl-/- mice have delayed recovery and prolonged axonal damage following cuprizone toxicity. Brain Res, 1240:1-11. (PubMed:18804096)
  7. Korshunov VA et al. (2006) Axl, a receptor tyrosine kinase, mediates flow-induced vascular remodeling. Circ Res, 98:1446-52. (PubMed:16627783)
  8. Leimeister C et al. (1999) Screen for genes regulated during early kidney morphogenesis. Dev Genet, 24:273-83. (PubMed:10322635)
  9. Lu Q et al. (1999) Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature, 398:723-8. (PubMed:10227296)
  10. Lu Q et al. (2001) Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science, 293:306-11. (PubMed:11452127)
  11. Orso F et al. (2009) AP-2alpha regulates migration of GN-11 neurons via a specific genetic programme involving the Axl receptor tyrosine kinase. BMC Biol, 7:25. (PubMed:19463168)
  12. Pierce A et al. (2008) Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration. Mol Endocrinol, 22:2481-95. (PubMed:18787040)
  13. Seitz HM et al. (2007) Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells. J Immunol, 178:5635-42. (PubMed:17442946)
  14. Shankar SL et al. (2006) Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis. J Neurosci, 26:5638-48. (PubMed:16723520)
  15. Sharif MN et al. (2006) Twist mediates suppression of inflammation by type I IFNs and Axl. J Exp Med, 203:1891-901. (PubMed:16831897)
  16. Wu H et al. (2008) High incidence of distal vaginal atresia in mice lacking Tyro3 RTK subfamily. Mol Reprod Dev, 75:1775-82. (PubMed:18393392)
  17. Xiong W et al. (2008) Gas6 and the Tyro 3 receptor tyrosine kinase subfamily regulate the phagocytic function of Sertoli cells. Reproduction, 135:77-87. (PubMed:18159085)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory