Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Slc27a2. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of September 18, 2009. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Slc27a2
  • participates in the following biological processes:
    • fatty acid transport ^[5]
    • long-chain fatty acid metabolic process ^[1]
    • very long-chain fatty acid metabolic process ^[1]
  • performs the following molecular functions:
    • fatty acid transporter activity ^[3]
    • long-chain fatty acid-CoA ligase activity ^[1]
    • very long-chain fatty acid-CoA ligase activity ^[1]
  • is located in the following cellular components:
    • endoplasmic reticulum ^[1]
    • mitochondrion ^[4]
    • peroxisome ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Slc27a2
  • participates in the following biological processes:
    • very long-chain fatty acid catabolic process ^[2]
  • performs the following molecular functions:
    • very long-chain fatty acid-CoA ligase activity ^[2]
  • is located in the following cellular components:
    • peroxisome ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Slc27a2:
  • participates in the following biological processes:
    • bile acid biosynthetic process
    • fatty acid alpha-oxidation
    • fatty acid beta-oxidation
    • long-chain fatty acid import
    • long-chain fatty acid metabolic process
    • methyl-branched fatty acid metabolic process
  • performs the following molecular functions:
    • enzyme binding
    • long-chain fatty acid-CoA ligase activity
    • phytanate-CoA ligase activity
    • pristanate-CoA ligase activity
    • receptor binding
    • very long-chain fatty acid-CoA ligase activity
  • is located in the following cellular components:
    • endoplasmic reticulum lumen
    • endoplasmic reticulum membrane
    • integral to endoplasmic reticulum membrane
    • integral to peroxisomal membrane
    • intracellular membrane-bounded organelle
    • peroxisomal membrane
    • peroxisome

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Summary text based on GO annotations supported by structural data

• Slc27a2 encodes a protein or proteins that contain the following InterPro domains: AMP-binding, conserved site, AMP-dependent synthetase/ligase, indicating that the gene product:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • catalytic activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Slc27a2 indicates that it:
  • participates in the following biological processes:
    • fatty acid metabolic process
    • lipid metabolic process
  • performs the following molecular functions:
    • ATP binding
    • ligase activity
    • nucleotide binding
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Heinzer AK et al. (2002) Mouse very long-chain acyl-CoA synthetase in X-linked adrenoleukodystrophy. J Biol Chem, 277:28765-73. (PubMed:12048192)
2. Heinzer AK et al. (2003) A very long-chain acyl-CoA synthetase-deficient mouse and its relevance to X-linked adrenoleukodystrophy. Hum Mol Genet, 12:1145-54. (PubMed:12719378)
3. Hirsch D et al. (1998) A family of fatty acid transporters conserved from mycobacterium to man. Proc Natl Acad Sci U S A, 95:8625-9. (PubMed:9671728)
4. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
5. Pirard M et al. (1997) Comparison of PMM1 with the phosphomannomutases expressed in rat liver and in human cells. FEBS Lett, 411:251-4. (PubMed:9271215)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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