Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Btd. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of December 7, 2012. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Biotinidase functions to recycle biotin in the body by cleaving biocytin (biotin-epsilon-lysine), a normal product of carboxylase degradation, resulting in regeneration of free biotin. Biotinidase has also been shown to have biotinyl-transferase activity. Defects in the biotinidase gene cause multiple carboxylase deficiency. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Btd
  • is located in the following cellular components:
    • apical part of cell ^[1]
    • nucleolus ^[1]
    • perikaryon ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Btd
  • participates in the following biological processes:
    • biotin metabolic process ^[2]
  • performs the following molecular functions:
    • biotinidase activity ^[2]

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Summary text based on GO annotations supported by structural data

• Btd encodes a protein or proteins that contain the following InterPro domains: Biotinidase, eukaryotic, Carbon-nitrogen hydrolase, indicating that the gene product:
  • participates in the following biological processes:
    • nitrogen compound metabolic process
  • performs the following molecular functions:
    • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Btd indicates that it:
  • performs the following molecular functions:
    • hydrolase activity
  • is located in the following cellular components:
    • extracellular region

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References

1. Brumwell CL et al. (2005) Biotinidase reveals the morphogenetic sequence in cochlea and cochlear nucleus of mice. Hear Res, 209:104-21. (PubMed:16107307)
2. Pindolia K et al. (2011) Development and characterization of a mouse with profound biotinidase deficiency: a biotin-responsive neurocutaneous disorder. Mol Genet Metab, 102:161-9. (PubMed:21051254)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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