Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Involved in several processes, including adrenal gland development; gonad development; and regulation of gonad development. Localizes to RNA polymerase II transcription regulator complex and nucleus. Is expressed in several structures, including central nervous system; endocrine gland; genitourinary system; hemolymphoid system; and respiratory system. Used to study hypogonadotropic hypogonadism. Human ortholog(s) of this gene implicated in 46,XX sex reversal 4; 46,XY sex reversal 3; Zellweger syndrome; premature ovarian failure; and spermatogenic failure 8. Orthologous to human NR5A1 (nuclear receptor subfamily 5 group A member 1).