Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Esrra. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Esrra
  • participates in the following biological processes:
    • positive regulation of transcription from RNA polymerase II promoter ^[2]
  • performs the following molecular functions:
    • DNA binding ^[2]
    • sequence-specific DNA binding transcription factor activity ^[2]
  • is located in the following cellular components:
    • nucleus ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Esrra
  • participates in the following biological processes:
    • positive regulation of transcription from RNA polymerase II promoter ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Esrra:
  • participates in the following biological processes:
    • cartilage development
    • positive regulation of transcription, DNA-dependent
    • regulation of cell proliferation
    • regulation of ossification
    • regulation of osteoblast differentiation
    • regulation of osteoclast differentiation
  • performs the following molecular functions:
    • protein domain specific binding

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Summary text based on GO annotations supported by structural data

• Esrra encodes a protein or proteins that contain the following InterPro domains: Nuclear hormone receptor, ligand-binding, Nuclear hormone receptor, ligand-binding, core, Oestrogen receptor-related nuclear receptor, Steroid hormone receptor, Zinc finger, NHR/GATA-type, Zinc finger, nuclear hormone receptor-type, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
    • steroid hormone mediated signaling pathway
  • performs the following molecular functions:
    • sequence-specific DNA binding
    • steroid binding
    • steroid hormone receptor activity
    • zinc ion binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Esrra indicates that it:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • metal ion binding

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References

1. Rasbach KA et al. (2010) PGC-1{alpha} regulates a HIF2{alpha}-dependent switch in skeletal muscle fiber types. Proc Natl Acad Sci U S A, null:null. (PubMed:21106753)
2. Zirngibl RA et al. (2008) Estrogen receptor-related receptor alpha (ERRalpha) regulates osteopontin expression through a non-canonical ERRalpha response element in a cell context-dependent manner. J Mol Endocrinol, 40:61-73. (PubMed:18234909)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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