Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Mta2. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Mta2
  • participates in the following biological processes:
    • negative regulation of transcription from RNA polymerase II promoter ^[5]
    • negative regulation of transcription, DNA-dependent ^[1]
    • positive regulation of transcription from RNA polymerase II promoter ^[5]
  • performs the following molecular functions:
    • histone deacetylase activity ^[9]
    • transcription factor binding transcription factor activity ^[1]
    • transcription regulatory region DNA binding ^[1]
  • is located in the following cellular components:
    • histone deacetylase complex ^[9]
    • nucleus ^{[2, 4, 5]}
    • NuRD complex ^[10]
• The gene product of Mta2 has been shown to bind to the gene products of Esrrb, Gata3, Hdac1, Hdac2, Mbd3, Mta1, Mta2, Pou5f1, Rbbp4, Rbbp7, Sall1, Sall4, Zfpm1. ^{[1, 2, 3, 6, 7, 8, 10]} Researchers have inferred, based on physical interactions, that the gene product of Mta2
  • performs the following molecular functions:
  • is located in the following cellular components:
    • NuRD complex ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Mta2
  • participates in the following biological processes:
    • DNA methylation ^[4]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Mta2:
  • performs the following molecular functions:
    • RNA polymerase II repressing transcription factor binding
    • RNA polymerase II transcription factor binding
  • is located in the following cellular components:
    • nucleus
    • NuRD complex
    • transcription factor complex

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Summary text based on GO annotations supported by structural data

• Mta2 encodes a protein or proteins that contain the following InterPro domains: Bromo adjacent homology (BAH) domain, ELM2 domain, Homeodomain-like, SANT domain, SANT/Myb domain, Zinc finger, GATA-type, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
  • performs the following molecular functions:
    • chromatin binding
    • DNA binding
    • sequence-specific DNA binding
    • sequence-specific DNA binding transcription factor activity
    • zinc ion binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Mta2 indicates that it:
  • performs the following molecular functions:
    • DNA binding
    • metal ion binding

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References

1. Hwang SS et al. (2010) GATA-binding protein-3 regulates T helper type 2 cytokine and ifng loci through interaction with metastasis-associated protein 2. Immunology, 131:50-8. (PubMed:20636338)
2. Kaji K et al. (2006) The NuRD component Mbd3 is required for pluripotency of embryonic stem cells. Nat Cell Biol, 8:285-92. (PubMed:16462733)
3. Kiefer SM et al. (2002) Murine sall1 represses transcription by recruiting a histone deacetylase complex. J Biol Chem, 277:14869-76. (PubMed:11836251)
4. Ma P et al. (2010) Metastasis Tumor Antigen 2 (MTA2) is involved in proper imprinted expression of H19 and Peg3 during mouse preimplantation development. Biol Reprod, 83:1027-35. (PubMed:20720167)
5. Matsusue K et al. (2001) Characterization of mouse metastasis-associated gene 2: genomic structure, nuclear localization signal, and alternative potentials as transcriptional activator and repressor. DNA Cell Biol, 20:603-11. (PubMed:11749719)
6. Pardo M et al. (2010) An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Cell Stem Cell, 6:382-95. (PubMed:20362542)
7. Snow JW et al. (2009) Translational isoforms of FOG1 regulate GATA1-interacting complexes. J Biol Chem, 284:29310-9. (PubMed:19654328)
8. van den Berg DL et al. (2010) An Oct4-centered protein interaction network in embryonic stem cells. Cell Stem Cell, 6:369-81. (PubMed:20362541)
9. Zhang Y et al. (1999) Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev, 13:1924-35. (PubMed:10444591)
10. Zoltewicz JS et al. (2004) Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis. Development, 131:3-14. (PubMed:14645126)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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