Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Def6. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]).[supplied by OMIM, Mar 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• The gene product of Def6 has been shown to bind to the gene products of Itga7. ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Def6:
  • is located in the following cellular components:
    • nucleus

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Summary text based on GO annotations supported by structural data

• Def6 encodes a protein or proteins that contain the following InterPro domains: Pleckstrin homology domain, Pleckstrin homology-like domain, indicating that the gene product:
  • performs the following molecular functions:
    • phospholipid binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Def6 indicates that it:
  • is located in the following cellular components:
    • cytoplasm
    • membrane
    • plasma membrane

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References

1. Samson T et al. (2007) Def-6, a guanine nucleotide exchange factor for Rac1, interacts with the skeletal muscle integrin chain alpha7A and influences myoblast differentiation. J Biol Chem, 282:15730-42. (PubMed:17403664)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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