Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Fbln5. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Fbln5
  • participates in the following biological processes:
    • extracellular matrix organization ^[1]
  • is located in the following cellular components:
    • elastic fiber ^[3]
    • extracellular matrix ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Fbln5
  • participates in the following biological processes:
    • elastic fiber assembly ^[3]
    • protein localization to cell surface ^[2]
    • regulation of removal of superoxide radicals ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Fbln5:
  • performs the following molecular functions:
    • protein C-terminus binding
  • is located in the following cellular components:
    • cytoplasm
    • extracellular space

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Summary text based on GO annotations supported by structural data

• Fbln5 encodes a protein or proteins that contain the following InterPro domains: EGF-like calcium-binding, EGF-like calcium-binding, conserved site, EGF-like, conserved site, EGF-type aspartate/asparagine hydroxylation site, Epidermal growth factor-like domain, indicating that the gene product:
  • performs the following molecular functions:
    • calcium ion binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Fbln5 indicates that it:
  • participates in the following biological processes:
    • cell adhesion
  • is located in the following cellular components:
    • extracellular region

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References

1. Manabe R et al. (2008) Transcriptome-based systematic identification of extracellular matrix proteins. Proc Natl Acad Sci U S A, 105:12849-54. (PubMed:18757743)
2. Nguyen AD et al. (2004) Fibulin-5 is a novel binding protein for extracellular superoxide dismutase. Circ Res, 95:1067-74. (PubMed:15528465)
3. Yanagisawa H et al. (2002) Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo. Nature, 415:168-71. (PubMed:11805834)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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