Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Rgs7. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Rgs7
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway ^[1]
    • regulation of G-protein coupled receptor protein signaling pathway ^[2]
  • is located in the following cellular components:
    • dendrite terminus ^[2]
    • nucleus ^[1]
    • plasma membrane ^[1]
• The gene product of Rgs7 has been shown to bind to the gene products of Gpr158. ^{[1, 2]}
• Researchers have inferred, based on genetic interactions, that the gene product of Rgs7
  • participates in the following biological processes:
    • regulation of G-protein coupled receptor protein signaling pathway based on interactions with Gpr158 ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Rgs7:
  • participates in the following biological processes:
    • regulation of G-protein coupled receptor protein signaling pathway
  • performs the following molecular functions:
    • G-protein beta-subunit binding
    • GTPase activator activity
  • is located in the following cellular components:
    • cytoplasm
    • cytosol
    • plasma membrane
    • protein complex

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Summary text based on GO annotations supported by structural data

• Rgs7 encodes a protein or proteins that contain the following InterPro domains: DEP domain, G-protein gamma-like domain, Regulator of G protein signalling, Regulator of G protein signalling superfamily, Regulator of G-protein signaling, domain 1, Winged helix-turn-helix transcription repressor DNA-binding, indicating that the gene product:
  • participates in the following biological processes:
    • intracellular signal transduction
    • termination of G-protein coupled receptor signaling pathway
  • performs the following molecular functions:
    • signal transducer activity
  • is located in the following cellular components:
    • heterotrimeric G-protein complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Rgs7 indicates that it:
  • participates in the following biological processes:
    • negative regulation of signal transduction

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References

1. Drenan RM et al. (2005) Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family. J Cell Biol, 169:623-33. (PubMed:15897264)
2. Orlandi C et al. (2012) GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes. J Cell Biol, 197:711-9. (PubMed:22689652)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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