Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Slc26a4. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. It is highly homologous to the SLC26A3 gene; they have similar genomic structures and this gene is located 3' of the SLC26A3 gene. The encoded protein has homology to sulfate transporters. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Slc26a4
  • is located in the following cellular components:
    • apical plasma membrane ^{[1, 2, 3]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Slc26a4
  • participates in the following biological processes:
    • regulation of pH ^[2]
    • regulation of protein localization ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Slc26a4:
  • participates in the following biological processes:
    • anion transport
    • chloride transport
    • inorganic anion transport
    • iodide transport
    • ion transmembrane transport
    • organ morphogenesis
  • performs the following molecular functions:
    • anion transmembrane transporter activity
    • chloride transmembrane transporter activity
    • iodide transmembrane transporter activity
  • is located in the following cellular components:
    • apical plasma membrane

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Summary text based on GO annotations supported by structural data

• Slc26a4 encodes a protein or proteins that contain the following InterPro domains: STAS domain, Sulphate anion transporter, Sulphate anion transporter, conserved site, Sulphate transporter, indicating that the gene product:
  • participates in the following biological processes:
    • sulfate transport
    • transmembrane transport
  • performs the following molecular functions:
    • secondary active sulfate transmembrane transporter activity
    • sulfate transmembrane transporter activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Slc26a4 indicates that it:
  • participates in the following biological processes:
    • transport
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Dou H et al. (2004) Co-expression of pendrin, vacuolar H+-ATPase alpha4-subunit and carbonic anhydrase II in epithelial cells of the murine endolymphatic sac. J Histochem Cytochem, 52:1377-84. (PubMed:15385584)
2. Kim YH et al. (2005) Intercalated cell H+/OH- transporter expression is reduced in Slc26a4 null mice. Am J Physiol Renal Physiol, 289:F1262-72. (PubMed:16144965)
3. Verlander JW et al. (2003) Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney. Am J Physiol Renal Physiol, 284:F323-37. (PubMed:12388412)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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