Automated description from the Alliance of Genome Resources (Release 5.2.2)
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding activity; and chromatin DNA binding activity. Involved in forebrain development and negative regulation of transcription by RNA polymerase II. Acts upstream of or within axonogenesis; dorsal/ventral axis specification; and eye development. Located in cytoplasm and nucleus. Is expressed in central nervous system; limb; and visual system. Orthologous to human VAX2 (ventral anterior homeobox 2).