Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Slc35a1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is found in the membrane of the Golgi apparatus, where it transports nucleotide sugars into the Golgi. One such nucleotide sugar is CMP-sialic acid, which is imported into the Golgi by the encoded protein and subsequently glycosylated. Defects in this gene are a cause of congenital disorder of glycosylation type 2F (CDG2F). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]

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Summary text based on GO annotations supported by structural data

• Slc35a1 encodes a protein or proteins that contain the following InterPro domains: Nucleotide-sugar transporter, UDP-galactose transporter, UDP/CMP-sugar transporter, indicating that the gene product:
  • participates in the following biological processes:
    • carbohydrate transport
    • nucleotide-sugar transport
  • performs the following molecular functions:
    • nucleotide-sugar transmembrane transporter activity
    • sugar:hydrogen symporter activity
  • is located in the following cellular components:
    • Golgi membrane
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Slc35a1 indicates that it:
  • participates in the following biological processes:
    • carbohydrate transport
    • transport
  • is located in the following cellular components:
    • Golgi apparatus
    • integral to membrane
    • membrane

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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