Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Slc11a2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Slc11a2
  • participates in the following biological processes:
    • cobalt ion transport ^{[9, 10, 11, 14, 17]}
    • ferrous iron import ^[18]
    • ferrous iron transport ^[14]
    • iron ion transport ^{[10, 11]}
    • proton transport ^[18]
  • performs the following molecular functions:
    • cobalt ion transmembrane transporter activity ^{[9, 10, 11, 14, 17]}
    • ferrous iron transmembrane transporter activity ^{[10, 14, 18]}
    • hydrogen ion transmembrane transporter activity ^[18]
    • iron ion transmembrane transporter activity ^[11]
  • is located in the following cellular components:
    • brush border ^[3]
    • cell surface ^[2]
    • early endosome ^[17]
    • endomembrane system ^[17]
    • endosome ^[12]
    • integral to plasma membrane ^[14]
    • plasma membrane ^{[4, 9, 12, 17]}
    • recycling endosome ^{[4, 9]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Slc11a2
  • participates in the following biological processes:
    • dendrite morphogenesis ^[5]
    • erythrocyte development ^[7]
    • ferrous iron import ^[4]
    • heme biosynthetic process ^[4]
    • iron ion transport ^{[6, 13]}
    • learning or memory ^[5]
    • multicellular organismal iron ion homeostasis ^{[1, 16]}
    • porphyrin-containing compound biosynthetic process ^[15]
    • porphyrin-containing compound metabolic process ^[8]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Slc11a2:
  • participates in the following biological processes:
    • activation of cysteine-type endopeptidase activity involved in apoptotic process
    • cadmium ion transmembrane transport
    • cellular response to oxidative stress
    • cobalt ion transport
    • copper ion transport
    • ferrous iron import
    • ferrous iron transport
    • lead ion transport
    • manganese ion transmembrane transport
    • manganese ion transport
    • multicellular organismal iron ion homeostasis
    • nickel cation transmembrane transport
    • nickel cation transport
    • response to manganese ion
    • transition metal ion transport
    • vanadium ion transport
    • zinc ion transmembrane transport
  • performs the following molecular functions:
    • cadmium ion binding
    • cadmium ion transmembrane transporter activity
    • cobalt ion binding
    • cobalt ion transmembrane transporter activity
    • copper ion binding
    • copper ion transmembrane transporter activity
    • ferrous iron transmembrane transporter activity
    • inorganic cation transmembrane transporter activity
    • iron ion binding
    • iron ion transmembrane transporter activity
    • lead ion transmembrane transporter activity
    • manganese ion binding
    • manganese ion transmembrane transporter activity
    • nickel cation binding
    • nickel cation transmembrane transporter activity
    • solute:hydrogen symporter activity
    • vanadium ion transmembrane transporter activity
    • zinc ion binding
    • zinc ion transmembrane transporter activity
  • is located in the following cellular components:
    • apical part of cell
    • apical plasma membrane
    • basal part of cell
    • cell surface
    • cytoplasm
    • cytoplasmic vesicle
    • early endosome
    • integral to membrane
    • late endosome
    • late endosome membrane
    • lysosomal membrane
    • lysosome
    • nucleus
    • paraferritin complex
    • perinuclear region of cytoplasm
    • plasma membrane
    • recycling endosome
    • trans-Golgi network
    • vacuole

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Summary text based on GO annotations supported by structural data

• Slc11a2 encodes a protein or proteins that contain the following InterPro domains: Natural resistance-associated macrophage protein, indicating that the gene product:
  • participates in the following biological processes:
    • transport
  • performs the following molecular functions:
    • transporter activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Slc11a2 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • iron ion homeostasis
    • transport
  • is located in the following cellular components:
    • membrane

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References

1. Bannerman RM et al. (1972) Hereditary microcytic anaemia in the mouse; studies in iron distribution and metabolism. Br J Haematol, 23:235-45. (PubMed:5070129)
2. Beisel KW et al. (2007) Diversity of Ca(2+)-activated K(+) channel transcripts in inner ear hair cells. Gene, 386:11-23. (PubMed:17097837)
3. Canonne-Hergaux F et al. (2000) The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border. Blood, 96:3964-70. (PubMed:11090085)
4. Canonne-Hergaux F et al. (2001) Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice. Blood, 98:3823-30. (PubMed:11739192)
5. Carlson ES et al. (2009) Iron is essential for neuron development and memory function in mouse hippocampus. J Nutr, 139:672-9. (PubMed:19211831)
6. Edwards JA et al. (1975) Red cell iron uptake in hereditary microcytic anemia. Blood, 46:381-8. (PubMed:807277)
7. Gunshin H et al. (2005) Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. J Clin Invest, 115:1258-1266. (PubMed:15849611)
8. Kreimer-Birnbaum M et al. (1972) Pyrrole pigments in normal and congenitally anaemic mice (+:+, W-W v , ha-ha, nb-nb, mk-mk, f-f and sla-Y). Comp Biochem Physiol A, 43:21-30. (PubMed:4404581)
9. Lam-Yuk-Tseung S et al. (2006) Identification of a tyrosine-based motif (YGSI) in the amino terminus of Nramp1 (Slc11a1) that is important for lysosomal targeting. J Biol Chem, 281:31677-88. (PubMed:16905747)
10. Lam-Yuk-Tseung S et al. (2003) Iron transport by Nramp2/DMT1: pH regulation of transport by 2 histidines in transmembrane domain 6. Blood, 101:3699-707. (PubMed:12522007)
11. Lam-Yuk-Tseung S et al. (2005) Carboxyl-Terminus Determinants of the Iron Transporter DMT1/SLC11A2 Isoform II (-IRE/1B) Mediate Internalization from the Plasma Membrane into Recycling Endosomes. Biochemistry, 44:12149-59. (PubMed:16142913)
12. Ohgami RS et al. (2005) Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat Genet, 37:1264-9. (PubMed:16227996)
13. Ohgami RS et al. (2005) nm1054: a spontaneous, recessive, hypochromic, microcytic anemia mutation in the mouse. Blood, 106:3625-31. (PubMed:15994289)
14. Picard V et al. (2000) Nramp 2 (DCT1/DMT1) expressed at the plasma membrane transports iron and other divalent cations into a calcein-accessible cytoplasmic pool. J Biol Chem, 275:35738-45. (PubMed:10942769)
15. Sassa S et al. (1978) Studies of erythrocyte protoporphyrin in anemic mutant mice: use of a modified hematofluorometer for the detection of heterozygotes for hemolytic disease. Exp Hematol, 6:479-87. (PubMed:658175)
16. Suzuki T et al. (2008) Normal cadmium uptake in microcytic anemia mk/mk mice suggests that DMT1 is not the only cadmium transporter in vivo. Toxicol Appl Pharmacol, 227:462-7. (PubMed:18076961)
17. Touret N et al. (2003) Dynamic traffic through the recycling compartment couples the metal transporter Nramp2 (DMT1) with the transferrin receptor. J Biol Chem, 278:25548-57. (PubMed:12724326)
18. Xu H et al. (2004) A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. PLoS Biol, 2:E50. (PubMed:15024413)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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