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Gene Ontology Classifications
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

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GO curators for mouse genes have assigned the following annotations to the gene product of Slc11a2. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Bannerman RM et al. (1972) Hereditary microcytic anaemia in the mouse; studies in iron distribution and metabolism. Br J Haematol, 23:235-45. (PubMed:5070129)
  2. Beisel KW et al. (2007) Diversity of Ca(2+)-activated K(+) channel transcripts in inner ear hair cells. Gene, 386:11-23. (PubMed:17097837)
  3. Canonne-Hergaux F et al. (2000) The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border. Blood, 96:3964-70. (PubMed:11090085)
  4. Canonne-Hergaux F et al. (2001) Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice. Blood, 98:3823-30. (PubMed:11739192)
  5. Carlson ES et al. (2009) Iron is essential for neuron development and memory function in mouse hippocampus. J Nutr, 139:672-9. (PubMed:19211831)
  6. Edwards JA et al. (1975) Red cell iron uptake in hereditary microcytic anemia. Blood, 46:381-8. (PubMed:807277)
  7. Gunshin H et al. (2005) Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. J Clin Invest, 115:1258-1266. (PubMed:15849611)
  8. Kreimer-Birnbaum M et al. (1972) Pyrrole pigments in normal and congenitally anaemic mice (+:+, W-W v , ha-ha, nb-nb, mk-mk, f-f and sla-Y). Comp Biochem Physiol A, 43:21-30. (PubMed:4404581)
  9. Lam-Yuk-Tseung S et al. (2006) Identification of a tyrosine-based motif (YGSI) in the amino terminus of Nramp1 (Slc11a1) that is important for lysosomal targeting. J Biol Chem, 281:31677-88. (PubMed:16905747)
  10. Lam-Yuk-Tseung S et al. (2003) Iron transport by Nramp2/DMT1: pH regulation of transport by 2 histidines in transmembrane domain 6. Blood, 101:3699-707. (PubMed:12522007)
  11. Lam-Yuk-Tseung S et al. (2005) Carboxyl-Terminus Determinants of the Iron Transporter DMT1/SLC11A2 Isoform II (-IRE/1B) Mediate Internalization from the Plasma Membrane into Recycling Endosomes. Biochemistry, 44:12149-59. (PubMed:16142913)
  12. Ohgami RS et al. (2005) Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat Genet, 37:1264-9. (PubMed:16227996)
  13. Ohgami RS et al. (2005) nm1054: a spontaneous, recessive, hypochromic, microcytic anemia mutation in the mouse. Blood, 106:3625-31. (PubMed:15994289)
  14. Picard V et al. (2000) Nramp 2 (DCT1/DMT1) expressed at the plasma membrane transports iron and other divalent cations into a calcein-accessible cytoplasmic pool. J Biol Chem, 275:35738-45. (PubMed:10942769)
  15. Sassa S et al. (1978) Studies of erythrocyte protoporphyrin in anemic mutant mice: use of a modified hematofluorometer for the detection of heterozygotes for hemolytic disease. Exp Hematol, 6:479-87. (PubMed:658175)
  16. Suzuki T et al. (2008) Normal cadmium uptake in microcytic anemia mk/mk mice suggests that DMT1 is not the only cadmium transporter in vivo. Toxicol Appl Pharmacol, 227:462-7. (PubMed:18076961)
  17. Touret N et al. (2003) Dynamic traffic through the recycling compartment couples the metal transporter Nramp2 (DMT1) with the transferrin receptor. J Biol Chem, 278:25548-57. (PubMed:12724326)
  18. Xu H et al. (2004) A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. PLoS Biol, 2:E50. (PubMed:15024413)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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