Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ddr2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ddr2
  • participates in the following biological processes:
    • collagen-activated tyrosine kinase receptor signaling pathway ^[3]
    • protein phosphorylation ^[3]
    • transmembrane receptor protein tyrosine kinase signaling pathway ^[3]
  • performs the following molecular functions:
    • protein tyrosine kinase collagen receptor activity ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ddr2
  • participates in the following biological processes:
    • biomineral tissue development ^[1]
    • chondrocyte proliferation ^[2]
    • collagen fibril organization ^[1]
    • endochondral bone growth ^[2]
    • positive regulation of cell proliferation ^[3]
    • positive regulation of extracellular matrix disassembly ^[3]
    • positive regulation of fibroblast migration ^[3]
    • positive regulation of fibroblast proliferation ^{[2, 3]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ddr2:
  • participates in the following biological processes:
    • collagen-activated tyrosine kinase receptor signaling pathway
    • peptidyl-tyrosine phosphorylation
    • positive regulation of osteoblast differentiation
    • positive regulation of protein kinase activity
    • positive regulation of sequence-specific DNA binding transcription factor activity
    • protein autophosphorylation
    • regulation of bone mineralization
  • performs the following molecular functions:
    • collagen binding
    • protein tyrosine kinase collagen receptor activity
    • transmembrane receptor protein tyrosine kinase activity
  • is located in the following cellular components:
    • apical plasma membrane

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Summary text based on GO annotations supported by structural data

• Ddr2 encodes a protein or proteins that contain the following InterPro domains: Coagulation factor 5/8 C-terminal type domain, Galactose-binding domain-like, Protein kinase, catalytic domain, Protein kinase-like domain, Serine-threonine/tyrosine-protein kinase catalytic domain, Tyrosine-protein kinase, active site, Tyrosine-protein kinase, catalytic domain, Tyrosine-protein kinase, receptor class II, conserved site, indicating that the gene product:
  • participates in the following biological processes:
    • cell adhesion
  • performs the following molecular functions:
    • ATP binding
    • protein kinase activity
    • protein tyrosine kinase activity
    • transferase activity, transferring phosphorus-containing groups
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ddr2 indicates that it:
  • participates in the following biological processes:
    • ossification
    • phosphorylation
  • performs the following molecular functions:
    • ATP binding
    • kinase activity
    • nucleotide binding
    • protein tyrosine kinase activity
    • transferase activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane
    • plasma membrane

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References

1. Flynn LA et al. (2010) Inhibition of collagen fibrillogenesis by cells expressing soluble extracellular domains of DDR1 and DDR2. J Mol Biol, 395:533-43. (PubMed:19900459)
2. Labrador JP et al. (2001) The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism. EMBO Rep, 2:446-52. (PubMed:11375938)
3. Olaso E et al. (2002) Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2. J Biol Chem, 277:3606-13. (PubMed:11723120)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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