Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Scn11a. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.[supplied by OMIM, Apr 2004]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Scn11a
  • participates in the following biological processes:
    • sodium ion transmembrane transport ^[2]
    • sodium ion transport ^[2]
  • performs the following molecular functions:
    • voltage-gated sodium channel activity ^[2]
  • is located in the following cellular components:
    • axon ^[2]
    • C-fiber ^[2]
    • plasma membrane ^[2]
• The gene product of Scn11a has been shown to bind to the gene products of Fgf12. ^[1]

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Summary text based on GO annotations supported by structural data

• Scn11a encodes a protein or proteins that contain the following InterPro domains: Ion transport domain, Sodium ion transport-associated, Voltage gated sodium channel, alpha subunit, indicating that the gene product:
  • participates in the following biological processes:
    • ion transmembrane transport
    • ion transport
    • transmembrane transport
  • performs the following molecular functions:
    • ion channel activity
  • is located in the following cellular components:
    • membrane
    • voltage-gated sodium channel complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Scn11a indicates that it:
  • participates in the following biological processes:
    • ion transmembrane transport
    • ion transport
    • regulation of ion transmembrane transport
    • sodium ion transmembrane transport
    • transport
  • performs the following molecular functions:
    • ion channel activity
    • sodium channel activity
    • voltage-gated ion channel activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Liu Cj et al. (2001) Fibroblast growth factor homologous factor 1B binds to the C terminus of the tetrodotoxin-resistant sodium channel rNav1.9a (NaN). J Biol Chem, 276:18925-33. (PubMed:11376006)
2. Rush AM et al. (2005) Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons. Eur J Neurosci, 22:39-49. (PubMed:16029194)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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