Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables voltage-gated sodium channel activity. Involved in several processes, including behavioral response to chemical pain; detection of stimulus involved in sensory perception of pain; and monoatomic cation transmembrane transport. Acts upstream of or within establishment of localization in cell and sodium ion transport. Located in C-fiber and plasma membrane. Is active in axonal growth cone and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; immune system; reproductive system; and sensory organ. Used to study familial episodic pain syndrome 3 and hereditary sensory neuropathy. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 3 and hereditary sensory and autonomic neuropathy type 7. Orthologous to human SCN11A (sodium voltage-gated channel alpha subunit 11).
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