Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Spry4. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002 [PubMed 12027893]).[supplied by OMIM, Mar 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Spry4
  • participates in the following biological processes:
    • negative regulation of MAP kinase activity ^[1]
• The gene product of Spry4 has been shown to bind to the gene products of Sos1, Spry1, Spry2, Spry4. ^[1]

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Summary text based on GO annotations supported by structural data

• Spry4 encodes a protein or proteins that contain the following InterPro domains: Sprouty, indicating that the gene product:
  • participates in the following biological processes:
    • multicellular organismal development
    • regulation of signal transduction
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Spry4 indicates that it:
  • participates in the following biological processes:
    • multicellular organismal development
  • is located in the following cellular components:
    • cytoplasm
    • membrane

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References

1. Ozaki K et al. (2005) Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms. J Cell Sci, 118:5861-71. (PubMed:16339969)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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