Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ash2l. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of July 5, 2011. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ash2l
  • is located in the following cellular components:
    • MLL1 complex ^[3]
• The gene product of Ash2l has been shown to bind to the gene products of Rbbp5, Tbx1. ^{[1, 2, 4, 5]}
• Researchers have inferred, based on genetic interactions, that the gene product of Ash2l
  • participates in the following biological processes:
    • positive regulation of transcription from RNA polymerase II promoter based on interactions with Tbx1 ^[5]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ash2l:
  • participates in the following biological processes:
    • histone H3-K4 methylation
    • positive regulation of cell proliferation
    • response to DNA damage stimulus
    • response to estrogen stimulus
  • performs the following molecular functions:
    • transcription regulatory region DNA binding
  • is located in the following cellular components:
    • histone methyltransferase complex
    • nucleus
    • Set1C/COMPASS complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ash2l indicates that it:
  • participates in the following biological processes:
    • chromatin modification
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • DNA binding
    • metal ion binding

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References

1. Ang YS et al. (2011) Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network. Cell, 145:183-97. (PubMed:21477851)
2. De Santa F et al. (2007) The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell, 130:1083-94. (PubMed:17825402)
3. Dou Y et al. (2005) Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell, 121:873-85. (PubMed:15960975)
4. Jiang H et al. (2011) Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains. Cell, 144:513-25. (PubMed:21335234)
5. Stoller JZ et al. (2010) Ash2l interacts with Tbx1 and is required during early embryogenesis. Exp Biol Med (Maywood), 235:569-76. (PubMed:20463296)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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