Automated description from the Alliance of Genome Resources
Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and R-SMAD binding activity. Involved in several processes, including ameboidal-type cell migration; nervous system development; and regulation of transcription by RNA polymerase II. Localizes to the nucleus. Used to study Mowat-Wilson syndrome and T-cell adult acute lymphocytic leukemia. Human ortholog(s) of this gene implicated in Hirschsprung's disease and Mowat-Wilson syndrome. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human ZEB2 (zinc finger E-box binding homeobox 2).