Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Oasl2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Oasl2
  • participates in the following biological processes:
    • metabolic process ^{[2, 3]}
    • purine nucleotide biosynthetic process ^[2]
  • performs the following molecular functions:
    • 2'-5'-oligoadenylate synthetase activity ^{[1, 2, 3]}
    • double-stranded RNA binding ^{[1, 2]}

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Summary text based on GO annotations supported by structural data

• Oasl2 encodes a protein or proteins that contain the following InterPro domains: 2'-5'-oligoadenylate synthase, 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal, 2-5-oligoadenylate synthetase, conserved site, 2-5-oligoadenylate synthetase, N-terminal, Ubiquitin, Ubiquitin supergroup, indicating that the gene product:
  • participates in the following biological processes:
    • defense response to virus
    • immune response
  • performs the following molecular functions:
    • ATP binding
    • RNA binding
    • transferase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Oasl2 indicates that it:
  • participates in the following biological processes:
    • defense response to virus
    • innate immune response
  • performs the following molecular functions:
    • ATP binding
    • metal ion binding
    • nucleotide binding
    • nucleotidyltransferase activity
    • RNA binding
    • transferase activity
• Annotations directly to cellular component for the gene Oasl2 indicate that MGI curators have found no experimental data [literature] to support further annotation to this category at this time.

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References

1. Eskildsen S et al. (2003) Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin-like family. Nucleic Acids Res, 31:3166-73. (PubMed:12799444)
2. Kakuta S et al. (2002) Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family. J Interferon Cytokine Res, 22:981-93. (PubMed:12396720)
3. Tiefenthaler M et al. (1999) M1204, a novel 2',5' oligoadenylate synthetase with a ubiquitin-like extension, is induced during maturation of murine dendritic cells. J Immunol, 163:760-5. (PubMed:10395668)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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