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Gene Ontology Classifications
kallikrein related-peptidase 8

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GO curators for mouse genes have assigned the following annotations to the gene product of Klk8. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
  1. He XP et al. (2001) Expression of neuropsin in oligodendrocytes after injury to the CNS. Neurosci Res, 39:455-62. (PubMed:11274744)
  2. Hirata A et al. (2001) Abnormalities of synapses and neurons in the hippocampus of neuropsin-deficient mice. Mol Cell Neurosci, 17:600-10. (PubMed:11273653)
  3. Kishibe M et al. (2007) Kallikrein 8 is involved in skin desquamation in cooperation with other kallikreins. J Biol Chem, 282:5834-41. (PubMed:17182622)
  4. Kitayoshi H et al. (1999) Effect of 12-O-tetradecanoyl-phorbol ester and incisional wounding on neuropsin mRNA and its protein expression in murine skin. Arch Dermatol Res, 291:333-8. (PubMed:10421059)
  5. Matsumoto-Miyai K et al. (2003) NMDA-dependent proteolysis of presynaptic adhesion molecule L1 in the hippocampus by neuropsin. J Neurosci, 23:7727-36. (PubMed:12944500)
  6. Nakamura Y et al. (2006) Role of neuropsin in formation and maturation of Schaffer-collateral L1cam-immunoreactive synaptic boutons. J Cell Sci, 119:1341-9. (PubMed:16537644)
  7. Oka T et al. (2002) Extracellular serine protease neuropsin (KLK8) modulates neurite outgrowth and fasciculation of mouse hippocampal neurons in culture. Neurosci Lett, 321:141-4. (PubMed:11880192)
  8. Scott FL et al. (2007) SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes. J Biochem, 142:435-42. (PubMed:17761692)
  9. Shimizu C et al. (1998) Characterization of recombinant and brain neuropsin, a plasticity-related serine protease. J Biol Chem, 273:11189-96. (PubMed:9556608)
  10. Tamura H et al. (2006) Neuropsin is essential for early processes of memory acquisition and Schaffer collateral long-term potentiation in adult mouse hippocampus in vivo. J Physiol, 570:541-51. (PubMed:16308352)
  11. Terayama R et al. (2007) Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury. Neuroscience, 148:175-87. (PubMed:17629414)
  12. Tomizawa K et al. (1999) Injury induces neuropsin mRNA in the central nervous system. Brain Res, 824:308-11. (PubMed:10196465)

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Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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