Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Klk8. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in four transcript variants encoding four different isoforms. The isoforms exhibit distinct patterns of expression that suggest roles in brain plasticity and ovarian cancer. [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Klk8
  • participates in the following biological processes:
    • metabolic process ^{[5, 9]}
    • neuron projection morphogenesis ^[7]
    • response to wounding ^{[1, 4, 12]}
  • performs the following molecular functions:
    • serine-type endopeptidase activity ^{[5, 9]}
  • is located in the following cellular components:
    • cytoplasm ^[8]
    • extracellular space ^[9]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Klk8
  • participates in the following biological processes:
    • cell death ^[11]
    • keratinocyte proliferation ^[3]
    • memory ^[10]
    • negative regulation of axon regeneration ^[11]
    • negative regulation of myelination ^[11]
    • regulation of synapse organization ^[2]
    • synapse organization ^[6]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Klk8:
  • performs the following molecular functions:
    • serine-type endopeptidase activity
  • is located in the following cellular components:
    • cytoplasm

---

Summary text based on GO annotations supported by structural data

• Klk8 encodes a protein or proteins that contain the following InterPro domains: Peptidase cysteine/serine, trypsin-like, Peptidase S1/S6, chymotrypsin/Hap, Peptidase S1/S6, chymotrypsin/Hap, active site, Peptidase S1A, chymotrypsin-type, indicating that the gene product:
  • participates in the following biological processes:
    • proteolysis
  • performs the following molecular functions:
    • catalytic activity

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Klk8 indicates that it:
  • participates in the following biological processes:
    • proteolysis
  • performs the following molecular functions:
    • hydrolase activity
    • peptidase activity
    • serine-type peptidase activity
  • is located in the following cellular components:
    • extracellular region

---

References

1. He XP et al. (2001) Expression of neuropsin in oligodendrocytes after injury to the CNS. Neurosci Res, 39:455-62. (PubMed:11274744)
2. Hirata A et al. (2001) Abnormalities of synapses and neurons in the hippocampus of neuropsin-deficient mice. Mol Cell Neurosci, 17:600-10. (PubMed:11273653)
3. Kishibe M et al. (2007) Kallikrein 8 is involved in skin desquamation in cooperation with other kallikreins. J Biol Chem, 282:5834-41. (PubMed:17182622)
4. Kitayoshi H et al. (1999) Effect of 12-O-tetradecanoyl-phorbol ester and incisional wounding on neuropsin mRNA and its protein expression in murine skin. Arch Dermatol Res, 291:333-8. (PubMed:10421059)
5. Matsumoto-Miyai K et al. (2003) NMDA-dependent proteolysis of presynaptic adhesion molecule L1 in the hippocampus by neuropsin. J Neurosci, 23:7727-36. (PubMed:12944500)
6. Nakamura Y et al. (2006) Role of neuropsin in formation and maturation of Schaffer-collateral L1cam-immunoreactive synaptic boutons. J Cell Sci, 119:1341-9. (PubMed:16537644)
7. Oka T et al. (2002) Extracellular serine protease neuropsin (KLK8) modulates neurite outgrowth and fasciculation of mouse hippocampal neurons in culture. Neurosci Lett, 321:141-4. (PubMed:11880192)
8. Scott FL et al. (2007) SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes. J Biochem, 142:435-42. (PubMed:17761692)
9. Shimizu C et al. (1998) Characterization of recombinant and brain neuropsin, a plasticity-related serine protease. J Biol Chem, 273:11189-96. (PubMed:9556608)
10. Tamura H et al. (2006) Neuropsin is essential for early processes of memory acquisition and Schaffer collateral long-term potentiation in adult mouse hippocampus in vivo. J Physiol, 570:541-51. (PubMed:16308352)
11. Terayama R et al. (2007) Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury. Neuroscience, 148:175-87. (PubMed:17629414)
12. Tomizawa K et al. (1999) Injury induces neuropsin mRNA in the central nervous system. Brain Res, 824:308-11. (PubMed:10196465)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---