Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ndufs4. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of November 26, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), or NADH:ubiquinone oxidoreductase, the first multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I plays a vital role in cellular ATP production, the primary source of energy for many crucial processes in living cells. It removes electrons from NADH and passes them by a series of different protein-coupled redox centers to the electron acceptor ubiquinone. In well-coupled mitochondria, the electron flux leads to ATP generation via the building of a proton gradient across the inner membrane. Complex I is composed of at least 41 subunits, of which 7 are encoded by the mitochondrial genome and the remainder by nuclear genes. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ndufs4
  • participates in the following biological processes:
    • oxidation-reduction process ^[3]
  • performs the following molecular functions:
    • NADH dehydrogenase (ubiquinone) activity ^[3]
  • is located in the following cellular components:
    • mitochondrial respiratory chain complex I ^[3]
    • mitochondrion ^{[1, 2]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ndufs4:
  • participates in the following biological processes:
    • brain development
    • cAMP-mediated signaling
    • cellular respiration
    • mitochondrial respiratory chain complex I assembly
    • positive regulation of fibroblast proliferation
    • reactive oxygen species metabolic process
    • regulation of protein phosphorylation
    • response to cAMP
  • performs the following molecular functions:
    • NADH dehydrogenase (ubiquinone) activity
  • is located in the following cellular components:
    • mitochondrial respiratory chain complex I
    • mitochondrion
    • respiratory chain complex I

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Summary text based on GO annotations supported by structural data

• Ndufs4 encodes a protein or proteins that contain the following InterPro domains: NADH dehydrogenase ubiquinone Fe-S protein 4, mitochondrial, indicating that the gene product:
  • participates in the following biological processes:
    • electron transport chain
  • performs the following molecular functions:
    • oxidoreductase activity, acting on NAD(P)H
  • is located in the following cellular components:
    • mitochondrial inner membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ndufs4 indicates that it:
  • participates in the following biological processes:
    • electron transport chain
    • transport
  • is located in the following cellular components:
    • membrane
    • mitochondrial inner membrane
    • respiratory chain

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References

1. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
2. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)
3. Scacco S et al. (2000) cAMP-dependent phosphorylation of the nuclear encoded 18-kDa (IP) subunit of respiratory complex I and activation of the complex in serum-starved mouse fibroblast cultures. J Biol Chem, 275:17578-82. (PubMed:10747996)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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