Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables chromatin DNA binding activity; histone deacetylase activity; and histone decrotonylase activity. Involved in several processes, including circadian regulation of gene expression; cornified envelope assembly; and establishment of skin barrier. Acts upstream of or within several processes, including negative regulation of cardiac muscle cell differentiation; negative regulation of transcription by RNA polymerase II; and regulation of mitotic cell cycle. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; embryo mesenchyme; and sensory organ. Used to study endometriosis. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human HDAC3 (histone deacetylase 3).