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Gene Ontology Classifications
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

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GO curators for mouse genes have assigned the following annotations to the gene product of Ppargc1a. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Aoi W et al. (2010) The microRNA miR-696 regulates PGC-1{alpha} in mouse skeletal muscle in response to physical activity. Am J Physiol Endocrinol Metab, 298:E799-806. (PubMed:20086200)
  2. Compe E et al. (2007) Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH. Nat Neurosci, 10:1414-22. (PubMed:17952069)
  3. Cooper MP et al. (2006) Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex. Genes Dev, 20:2996-3009. (PubMed:17050673)
  4. Fan M et al. (2004) Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Genes Dev, 18:278-89. (PubMed:14744933)
  5. Finck BN et al. (2006) Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. Cell Metab, 4:199-210. (PubMed:16950137)
  6. Guan HP et al. (2005) Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. Genes Dev, 19:453-61. (PubMed:15681609)
  7. Hasumi H et al. (2012) Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN. J Natl Cancer Inst, 104:1750-64. (PubMed:23150719)
  8. Kajimura S et al. (2008) Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev, 22:1397-409. (PubMed:18483224)
  9. Kim HB et al. (2010) Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors. Mol Cell Biol, 30:3126-39. (PubMed:20385772)
  10. Kong X et al. (2014) IRF4 is a key thermogenic transcriptional partner of PGC-1alpha. Cell, 158:69-83. (PubMed:24995979)
  11. Lau P et al. (2004) RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR. J Biol Chem, 279:36828-40. (PubMed:15199055)
  12. Liu C et al. (2007) Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism. Nature, 447:477-81. (PubMed:17476214)
  13. Napal L et al. (2005) An intronic peroxisome proliferator-activated receptor-binding sequence mediates fatty acid induction of the human carnitine palmitoyltransferase 1A. J Mol Biol, 354:751-9. (PubMed:16271724)
  14. Nedumaran B et al. (2009) DAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expression. J Biol Chem, 284:27511-23. (PubMed:19651776)
  15. Nemoto S et al. (2005) SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}. J Biol Chem, 280:16456-60. (PubMed:15716268)
  16. Pan D et al. (2009) Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism. Cell, 137:73-86. (PubMed:19345188)
  17. Rasbach KA et al. (2010) PGC-1{alpha} regulates a HIF2{alpha}-dependent switch in skeletal muscle fiber types. Proc Natl Acad Sci U S A, null:null. (PubMed:21106753)
  18. Reed C et al. (2014) RB tumor suppressive function in response to xenobiotic hepatocarcinogens. Am J Pathol, 184:1853-9. (PubMed:24726645)
  19. Rodgers JT et al. (2005) Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature, 434:113-8. (PubMed:15744310)
  20. Sano M et al. (2007) Menage-a-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1. Cell Metab, 5:129-42. (PubMed:17276355)
  21. Seale P et al. (2007) Transcriptional control of brown fat determination by PRDM16. Cell Metab, 6:38-54. (PubMed:17618855)
  22. Volakakis N et al. (2010) NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection. Proc Natl Acad Sci U S A, 107:12317-22. (PubMed:20566846)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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