Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in lymphocyte differentiation; positive regulation of transcription by RNA polymerase II; and regulation of B cell activation. Acts upstream of or within response to bacterium. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and liver and biliary system. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human IKZF3 (IKAROS family zinc finger 3).