Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II; regulation of B cell activation; and response to bacterium. Localizes to cytoplasm and nucleus. Is expressed in Peyer's patch; genitourinary system; immune system; lung; and spinal cord. Used to study systemic lupus erythematosus. Orthologous to human IKZF3 (IKAROS family zinc finger 3).