Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and poly-pyrimidine tract binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; lymphocyte differentiation; and positive regulation of macromolecule biosynthetic process. Located in nucleus. Part of pericentric heterochromatin. Is expressed in several structures, including aorta-gonad-mesonephros; brain; hemolymphoid system; lower urinary tract; and yolk sac. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; colorectal cancer; and common variable immunodeficiency 13. Orthologous to human IKZF1 (IKAROS family zinc finger 1).