Automated description from the Alliance of Genome Resources
Exhibits several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in several processes, including hematopoietic or lymphoid organ development; neural retina development; and regulation of transcription by RNA polymerase II. Localizes to the nucleus; pericentric heterochromatin; and protein-DNA complex. Human ortholog(s) of this gene implicated in common variable immunodeficiency and precursor B lymphoblastic lymphoma/leukemia. Is expressed in several structures, including brain; dorsal aorta; genitourinary system; hemolymphoid system; and yolk sac. Orthologous to human IKZF1 (IKAROS family zinc finger 1).