Automated description from the Alliance of Genome Resources (Release 5.2.2)
Predicted to enable several functions, including cell adhesion molecule binding activity; protein C-terminus binding activity; and protein tyrosine kinase binding activity. Acts upstream of or within TNFSF11-mediated signaling pathway and negative regulation of osteoclast development. Located in nucleus; plasma membrane; and tight junction. Is expressed in several structures, including early conceptus; genitourinary system; inner ear; neural ectoderm; and tooth. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 51; disease of metabolism; and progressive familial intrahepatic cholestasis 4. Orthologous to human TJP2 (tight junction protein 2).