Automated description from the Alliance of Genome Resources (Release 3.1.1)
Predicted to have several functions, including protein C-terminus binding activity; protein tyrosine kinase binding activity; and protein-macromolecule adaptor activity. Involved in TNFSF11-mediated signaling pathway and negative regulation of osteoclast development. Localizes to nucleus; plasma membrane; and tight junction. Is expressed in several structures, including early embryo; genitourinary system; inner ear; lower jaw tooth; and neural ectoderm. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 51; disease of metabolism; and progressive familial intrahepatic cholestasis 4. Orthologous to human TJP2 (tight junction protein 2).