Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Mad1l1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Mad1l1:
  • is located in the following cellular components:
    • actin cytoskeleton
    • cytoplasm
    • mitochondrion
    • nucleus

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Summary text based on GO annotations supported by structural data

• Mad1l1 encodes a protein or proteins that contain the following InterPro domains: Mitotic checkpoint, indicating that the gene product:
  • participates in the following biological processes:
    • mitotic cell cycle spindle assembly checkpoint

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Mad1l1 indicates that it:
  • participates in the following biological processes:
    • cell cycle
    • cell division
    • mitosis
  • is located in the following cellular components:
    • chromosome
    • chromosome, centromeric region
    • cytoskeleton
    • kinetochore

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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