Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Fkbp8. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Fkbp8
  • participates in the following biological processes:
    • dorsal/ventral neural tube patterning ^[2]
  • is located in the following cellular components:
    • integral to endoplasmic reticulum membrane ^[1]
    • mitochondrial envelope ^[1]
    • mitochondrion ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Fkbp8
  • participates in the following biological processes:
    • camera-type eye development ^[1]
    • cell fate specification ^{[1, 2]}
    • dorsal/ventral neural tube patterning ^[2]
    • dorsal/ventral pattern formation ^[1]
    • neural tube development ^[2]
    • positive regulation of BMP signaling pathway ^[2]
    • smoothened signaling pathway ^[1]
• Researchers have inferred, based on genetic interactions, that the gene product of Fkbp8
  • participates in the following biological processes:
    • dorsal/ventral neural tube patterning based on interactions with Gli2, Kif3a ^[2]
    • multicellular organism growth based on interactions with Smo ^[2]
    • regulation of BMP signaling pathway based on interactions with Gli2 ^[2]
    • regulation of gene expression based on interactions with Smo ^[2]
    • smoothened signaling pathway based on interactions with Shh ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Fkbp8:
  • participates in the following biological processes:
    • peptidyl-proline modification
  • performs the following molecular functions:
    • FK506 binding
    • peptidyl-prolyl cis-trans isomerase activity

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Summary text based on GO annotations supported by structural data

• Fkbp8 encodes a protein or proteins that contain the following InterPro domains: Elongated TPR repeat-containing domain, Peptidyl-prolyl cis-trans isomerase, FKBP-type, Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain, Tetratricopeptide repeat, Tetratricopeptide repeat-containing domain, Tetratricopeptide TPR-1, Tetratricopeptide-like helical, indicating that the gene product:
  • participates in the following biological processes:
    • protein folding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Fkbp8 indicates that it:
  • participates in the following biological processes:
    • apoptotic process
    • protein folding
  • performs the following molecular functions:
    • isomerase activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Bulgakov OV et al. (2004) FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues. Development, 131:2149-59. (PubMed:15105374)
2. Cho A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev Biol, 321:27-39. (PubMed:18590716)
3. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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