Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Chi3l1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Chi3l1
  • participates in the following biological processes:
    • activation of NF-kappaB-inducing kinase activity ^[1]
    • interleukin-8 secretion ^[1]
    • positive regulation of peptidyl-threonine phosphorylation ^[1]
    • positive regulation of protein kinase B signaling cascade ^[1]
  • is located in the following cellular components:
    • cytoplasm ^[1]
    • endoplasmic reticulum ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Chi3l1:
  • participates in the following biological processes:
    • lung development
    • positive regulation of angiogenesis
    • positive regulation of ERK1 and ERK2 cascade
    • positive regulation of protein kinase B signaling cascade
  • performs the following molecular functions:
    • chitin binding
  • is located in the following cellular components:
    • extracellular space

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Summary text based on GO annotations supported by structural data

• Chi3l1 encodes a protein or proteins that contain the following InterPro domains: Chitinase II, Glycoside hydrolase, catalytic domain, Glycoside hydrolase, family 18, catalytic domain, Glycoside hydrolase, superfamily, indicating that the gene product:
  • participates in the following biological processes:
    • carbohydrate metabolic process
    • chitin catabolic process
  • performs the following molecular functions:
    • catalytic activity
    • cation binding
    • chitinase activity
    • hydrolase activity, hydrolyzing O-glycosyl compounds

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Chi3l1 indicates that it:
  • is located in the following cellular components:
    • extracellular region

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References

1. Chen CC et al. (2011) Carbohydrate-binding motif in chitinase 3-like 1 (CHI3L1/YKL-40) specifically activates Akt signaling pathway in colonic epithelial cells. Clin Immunol, 140:268-75. (PubMed:21546314)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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