Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Sema3e. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Sema3e
  • participates in the following biological processes:
    • negative regulation of angiogenesis ^[3]
    • negative regulation of cell-matrix adhesion ^[3]
    • patterning of blood vessels ^[2]
    • regulation of actin cytoskeleton reorganization ^[3]
    • regulation of cell shape ^{[2, 3]}
    • semaphorin-plexin signaling pathway ^[2]
    • sprouting angiogenesis ^[3]
    • synapse organization ^[1]

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Summary text based on GO annotations supported by structural data

• Sema3e encodes a protein or proteins that contain the following InterPro domains: Immunoglobulin, Immunoglobulin subtype, Immunoglobulin-like domain, Plexin-like fold, Plexin/semaphorin/integrin, Semaphorin, Semaphorin 3E, Semaphorin/CD100 antigen, WD40/YVTN repeat-like-containing domain, indicating that the gene product:
  • participates in the following biological processes:
    • multicellular organismal development
  • performs the following molecular functions:
    • receptor activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Sema3e indicates that it:
  • participates in the following biological processes:
    • angiogenesis
    • cell differentiation
    • multicellular organismal development
    • nervous system development

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References

1. Ding JB et al. (2012) Semaphorin 3E-Plexin-D1 signaling controls pathway-specific synapse formation in the striatum. Nat Neurosci, 15:215-23. (PubMed:22179111)
2. Gu C et al. (2005) Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Science, 307:265-8. (PubMed:15550623)
3. Sakurai A et al. (2010) Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras. Mol Cell Biol, 30:3086-98. (PubMed:20385769)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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