About   Help   FAQ
Gene Ontology Classifications
purinergic receptor P2X, ligand-gated ion channel, 7

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of P2rx7. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of July 28, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Adriouch S et al. (2002) Cutting Edge: A Natural P451L Mutation in the Cytoplasmic Domain Impairs the Function of the Mouse P2X7 Receptor. J Immunol, 169:4108-12. (PubMed:12370338)
  2. Aswad F et al. (2005) High sensitivity of CD4+CD25+ regulatory T cells to extracellular metabolites nicotinamide adenine dinucleotide and ATP: a role for P2X7 receptors. J Immunol, 175:3075-83. (PubMed:16116196)
  3. Aswad F et al. (2006) P2X(7) receptor expression levels determine lethal effects of a purine based danger signal in T lymphocytes. Cell Immunol, 243:58-65. (PubMed:17286969)
  4. Auger R et al. (2005) A role for mitogen-activated protein kinase(Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death. J Biol Chem, 280:28142-51. (PubMed:15937334)
  5. Bianco F et al. (2005) Astrocyte-derived ATP induces vesicle shedding and IL-1beta release from microglia. J Immunol, 174:7268-77. (PubMed:15905573)
  6. Chen L et al. (2006) Exacerbation of experimental autoimmune encephalomyelitis in P2X7R-/- mice: evidence for loss of apoptotic activity in lymphocytes. J Immunol, 176:3115-26. (PubMed:16493071)
  7. Chessell IP et al. (2005) Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain. Pain, 114:386-96. (PubMed:15777864)
  8. Denlinger LC et al. (2001) Cutting edge: the nucleotide receptor P2X7 contains multiple protein- and lipid-interaction motifs including a potential binding site for bacterial lipopolysaccharide. J Immunol, 167:1871-6. (PubMed:11489964)
  9. Fairbairn IP et al. (2001) ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X(7)-dependent process inducing bacterial death by phagosome-lysosome fusion. J Immunol, 167:3300-7. (PubMed:11544318)
  10. Fortes FS et al. (2004) Modulation of intercellular communication in macrophages: possible interactions between GAP junctions and P2 receptors. J Cell Sci, 117:4717-26. (PubMed:15331634)
  11. Franke H et al. (2005) P2X(7) receptor-mRNA and -protein in the mouse retina; changes during retinal degeneration in BALBCrds mice. Neurochem Int, 47:235-42. (PubMed:15964665)
  12. Garcia-Marcos M et al. (2005) Role of sodium in mitochondrial membrane depolarization induced by P2X7 receptor activation in submandibular glands. FEBS Lett, 579:5407-13. (PubMed:16198349)
  13. Goncalves RG et al. (2006) The role of purinergic P2X7 receptors in the inflammation and fibrosis of unilateral ureteral obstruction in mice. Kidney Int, 70:1599-606. (PubMed:16969386)
  14. Kawamura H et al. (2006) P2X7 receptors regulate NKT cells in autoimmune hepatitis. J Immunol, 176:2152-60. (PubMed:16455971)
  15. Ke HZ et al. (2003) Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption. Mol Endocrinol, 17:1356-67. (PubMed:12677010)
  16. Kerur N et al. (2013) TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy. Invest Ophthalmol Vis Sci, 54:7395-401. (PubMed:24114535)
  17. Labasi JM et al. (2002) Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response. J Immunol, 168:6436-45. (PubMed:12055263)
  18. Le Stunff H et al. (2004) The Pro-451 to Leu polymorphism within the C-terminal tail of P2X7 receptor impairs cell death but not phospholipase D activation in murine thymocytes. J Biol Chem, 279:16918-26. (PubMed:14761980)
  19. Lepine S et al. (2006) ATP-induced apoptosis of thymocytes is mediated by activation of P2 X 7 receptor and involves de novo ceramide synthesis and mitochondria. Biochim Biophys Acta, 1761:73-82. (PubMed:16325464)
  20. Li J et al. (2005) The P2X7 nucleotide receptor mediates skeletal mechanotransduction. J Biol Chem, 280:42952-9. (PubMed:16269410)
  21. Lu H et al. (2007) P2X(7) receptors mediate NADH transport across the plasma membranes of astrocytes. Biochem Biophys Res Commun, 362:946-50. (PubMed:17803959)
  22. Makui H et al. (2005) Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading. Blood, 106:2189-95. (PubMed:15914561)
  23. Marin-Garcia P et al. (2008) Synaptic terminals from mice midbrain exhibit functional P2X(7) receptor. Neuroscience, 151:361-73. (PubMed:18082965)
  24. Moores TS et al. (2005) Properties of presynaptic P2X(7)-like receptors at the neuromuscular junction. Brain Res, 1034:40-50. (PubMed:15713258)
  25. Ousingsawat J et al. (2015) Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages. Nat Commun, 6:6245. (PubMed:25651887)
  26. Panupinthu N et al. (2007) P2X7 nucleotide receptors mediate blebbing in osteoblasts through a pathway involving lysophosphatidic acid. J Biol Chem, 282:3403-12. (PubMed:17135244)
  27. Panupinthu N et al. (2008) P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis. J Cell Biol, 181:859-71. (PubMed:18519738)
  28. Papp L et al. (2004) Lack of ATP-evoked GABA and glutamate release in the hippocampus of P2X7 receptor-/- mice. Neuroreport, 15:2387-91. (PubMed:15640761)
  29. Papp L et al. (2007) P2X7 receptor mediated phosphorylation of p38MAP kinase in the hippocampus. Biochem Biophys Res Commun, 355:568-74. (PubMed:17306762)
  30. Pelegrin P et al. (2008) P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage. J Immunol, 180:7147-57. (PubMed:18490713)
  31. Pfeiffer ZA et al. (2007) Nucleotide receptor signaling in murine macrophages is linked to reactive oxygen species generation. Free Radic Biol Med, 42:1506-16. (PubMed:17448897)
  32. Sanchez-Nogueiro J et al. (2005) Characterization of a functional P2X(7)-like receptor in cerebellar granule neurons from P2X(7) knockout mice. FEBS Lett, 579:3783-8. (PubMed:15978588)
  33. Sikora A et al. (1999) Cutting edge: purinergic signaling regulates radical-mediated bacterial killing mechanisms in macrophages through a P2X7-independent mechanism. J Immunol, 163:558-61. (PubMed:10395640)
  34. Solle M et al. (2001) Altered cytokine production in mice lacking P2X(7) receptors. J Biol Chem, 276:125-32. (PubMed:11016935)
  35. Taylor SR et al. (2008) Sequential shrinkage and swelling underlie P2X7-stimulated lymphocyte phosphatidylserine exposure and death. J Immunol, 180:300-8. (PubMed:18097031)
  36. Traves PG et al. (2013) Selective Impairment of P2Y Signaling by Prostaglandin E2 in Macrophages: Implications for Ca2+-Dependent Responses. J Immunol, 190:4226-35. (PubMed:23479225)
  37. Wilson HL et al. (2004) Secretion of intracellular IL-1 receptor antagonist (type 1) is dependent on P2X7 receptor activation. J Immunol, 173:1202-8. (PubMed:15240711)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.0
The Jackson Laboratory