Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Adamts4. (This text reflects annotations as of Thursday, January 16, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Adamts4
  • participates in the following biological processes:
    • proteolysis ^{[1, 2]}
  • performs the following molecular functions:
    • metalloendopeptidase activity ^[1]
    • metallopeptidase activity ^[2]
• The gene product of Adamts4 has been shown to bind to the gene products of Coch. ^[1]
• Researchers have inferred, based on genetic interactions, that the gene product of Adamts4
  • participates in the following biological processes:
    • defense response to bacterium based on interactions with Adamts5 ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Adamts4:
  • performs the following molecular functions:
    • metallopeptidase activity
    • protease binding
  • is located in the following cellular components:
    • extracellular space

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Summary text based on GO annotations supported by structural data

• Adamts4 encodes a protein or proteins that contain the following InterPro domains: ADAM-TS Spacer 1, Metallopeptidase, catalytic domain, Peptidase M12B, ADAM-TS, Peptidase M12B, ADAM/reprolysin, Peptidase M12B, propeptide, Thrombospondin, type 1 repeat, indicating that the gene product:
  • performs the following molecular functions:
    • zinc ion binding
  • is located in the following cellular components:
    • extracellular matrix
    • proteinaceous extracellular matrix

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Adamts4 indicates that it:
  • performs the following molecular functions:
    • hydrolase activity
    • metal ion binding
    • peptidase activity
  • is located in the following cellular components:
    • extracellular region
    • proteinaceous extracellular matrix

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References

1. Py BF et al. (2013) Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity. Immunity, 38:1063-72. (PubMed:23684986)
2. Somerville RP et al. (2004) ADAMTS7B, the full-length product of the ADAMTS7 gene, is a chondroitin sulfate proteoglycan containing a mucin domain. J Biol Chem, 279:35159-75. (PubMed:15192113)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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