Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Myh3. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. Mutations in this gene have been associated with two congenital contracture (arthrogryposis) syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Myh3
  • is located in the following cellular components:
    • contractile fiber ^[1]
    • myosin complex ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Myh3:
  • participates in the following biological processes:
    • ATP catabolic process
    • skeletal muscle contraction
  • performs the following molecular functions:
    • actin filament binding
    • microfilament motor activity
  • is located in the following cellular components:
    • extracellular vesicular exosome

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Summary text based on GO annotations supported by structural data

• Myh3 encodes a protein or proteins that contain the following InterPro domains: IQ motif, EF-hand binding site, Myosin head, motor domain, Myosin S1 fragment, N-terminal, Myosin tail, Myosin, N-terminal, SH3-like, Myosin-like IQ motif-containing domain, P-loop containing nucleoside triphosphate hydrolase, indicating that the gene product:
  • performs the following molecular functions:
    • ATP binding
    • motor activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Myh3 indicates that it:
  • performs the following molecular functions:
    • actin binding
    • ATP binding
    • calmodulin binding
    • nucleotide binding
  • is located in the following cellular components:
    • cytoplasm
    • myosin filament

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References

1. Lechner BE et al. (2006) Developmental regulation of biglycan expression in muscle and tendon. Muscle Nerve, 34:347-55. (PubMed:16810681)
2. Smith TH et al. (1992) Distinct myogenic programs of embryonic and fetal mouse muscle cells: expression of the perinatal myosin heavy chain isoform in vitro. Dev Biol, 149:16-26. (PubMed:1728586)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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