Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Neurod1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Neurod1
  • participates in the following biological processes:
    • amacrine cell differentiation ^[6]
    • negative regulation of JAK-STAT cascade ^[10]
    • positive regulation of apoptotic process ^[16]
    • positive regulation of cell differentiation ^{[6, 16]}
    • positive regulation of neuron differentiation ^[19]
    • positive regulation of sequence-specific DNA binding transcription factor activity ^[13]
    • positive regulation of transcription from RNA polymerase II promoter ^{[16, 19]}
    • positive regulation of transcription, DNA-dependent ^{[8, 13]}
    • regulation of intestinal epithelial structure maintenance ^[16]
    • signal transduction involved in regulation of gene expression ^[12]
  • performs the following molecular functions:
    • chromatin binding ^[19]
    • DNA binding ^[8]
    • E-box binding ^[13]
    • sequence-specific DNA binding ^{[4, 11]}
  • is located in the following cellular components:
    • cytoplasm ^[11]
    • intracellular part ^{[4, 7]}
    • nucleus ^{[5, 11]}
• The gene product of Neurod1 has been shown to bind to the gene products of Ep300, Rb1, Rbl1. ^{[1, 16]} Researchers have inferred, based on physical interactions, that the gene product of Neurod1
  • performs the following molecular functions:
    • protein heterodimerization activity ^[11]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Neurod1
  • participates in the following biological processes:
    • anterior/posterior pattern specification ^[3]
    • cerebellum development ^[15]
    • dentate gyrus development ^{[14, 15]}
    • embryonic organ morphogenesis ^[17]
    • endocrine pancreas development ^{[14, 17]}
    • enteroendocrine cell differentiation ^[17]
    • glucose homeostasis ^[17]
    • hindbrain development ^[3]
    • inner ear development ^[9]
    • negative regulation of apoptotic process ^[17]
    • positive regulation of transcription from RNA polymerase II promoter ^[4]
    • regulation of cell cycle arrest ^[16]
• Researchers have inferred, based on genetic interactions, that the gene product of Neurod1
  • participates in the following biological processes:
    • camera-type eye development based on interactions with Neurod4 ^[6]
    • cell fate commitment based on interactions with Neurod4 ^[6]
    • dentate gyrus development based on interactions with Neurod6 ^[18]
    • pancreatic A cell fate commitment based on interactions with Nkx2-2 ^[2]
    • pancreatic PP cell fate commitment based on interactions with Nkx2-2 ^[2]
    • positive regulation of transcription from RNA polymerase II promoter based on interactions with Nr4a1, Rb1 ^[1]
• Based on the experimental annotations above, MGI curators have inferred, that the gene product of Neurod1
  • is located in the following cellular components:
    • nucleus ^[8]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Neurod1:
  • participates in the following biological processes:
    • cellular response to glucose stimulus
    • insulin secretion
    • nitric oxide mediated signal transduction
    • nucleocytoplasmic transport
    • positive regulation of neuron differentiation
    • positive regulation of sequence-specific DNA binding transcription factor activity
    • positive regulation of transcription from RNA polymerase II promoter
    • positive regulation of transcription regulatory region DNA binding
    • response to glucose stimulus
  • performs the following molecular functions:
    • double-stranded DNA binding
    • E-box binding
    • protein heterodimerization activity
    • RNA polymerase II activating transcription factor binding
    • RNA polymerase II transcription coactivator activity
    • sequence-specific DNA binding transcription factor activity
    • transcription coactivator activity
    • transcription factor binding
  • is located in the following cellular components:
    • cytoplasm
    • nucleus

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Summary text based on GO annotations supported by structural data

• Neurod1 encodes a protein or proteins that contain the following InterPro domains: Helix-loop-helix domain, Neurogenic differentiation factor, domain of unknown function, Transcription factor, basic helix-loop-helix, NeuroD, indicating that the gene product:
  • performs the following molecular functions:
    • protein dimerization activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Neurod1 indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • multicellular organismal development
    • nervous system development
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent

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References

1. Batsche E et al. (2005) Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription. J Biol Chem, 280:16088-95. (PubMed:15701640)
2. Chao CS et al. (2007) Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells. Dev Biol, 312:523-32. (PubMed:17988662)
3. Cho JH et al. (2006) Preferential posterior cerebellum defect in BETA2/NeuroD1 knockout mice is the result of differential expression of BETA2/NeuroD1 along anterior-posterior axis. Dev Biol, 290:125-38. (PubMed:16368089)
4. Chu K et al. (2005) Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion. Diabetes, 54:1064-73. (PubMed:15793245)
5. Davies D et al. (2002) Differential expression of alpha3 and alpha6 integrins in the developing mouse inner ear. J Comp Neurol, 445:122-32. (PubMed:11891657)
6. Inoue T et al. (2002) Math3 and NeuroD regulate amacrine cell fate specification in the retina. Development, 129:831-42. (PubMed:11861467)
7. Jensen J et al. (2000) Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. Diabetes, 49:163-76. (PubMed:10868931)
8. Kataoka K et al. (2002) MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene. J Biol Chem, 277:49903-10. (PubMed:12368292)
9. Kim WY et al. (2001) NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development. Development, 128:417-26. (PubMed:11152640)
10. Kwon IS et al. (2009) Expression of Disabled 1 suppresses astroglial differentiation in neural stem cells. Mol Cell Neurosci, 40:50-61. (PubMed:18848628)
11. Lavoie PL et al. (2008) Developmental Dependence on NurRE and EboxNeuro for Expression of Pituitary Proopiomelanocortin. Mol Endocrinol, 22:1647-57. (PubMed:18388149)
12. Lee D et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell, 2:497-507. (PubMed:18462699)
13. Lin CH et al. (2004) Regulation of neuroD2 expression in mouse brain. Dev Biol, 265:234-45. (PubMed:14697366)
14. Liu M et al. (2000) Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy [published erratum appears in Proc Natl Acad Sci U S A 2000 May 9;97(10):5679] Proc Natl Acad Sci U S A, 97:865-70. (PubMed:10639171)
15. Miyata T et al. (1999) NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus. Genes Dev, 13:1647-52. (PubMed:10398678)
16. Mutoh H et al. (1998) The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells. Genes Dev, 12:820-30. (PubMed:9512516)
17. Naya FJ et al. (1997) Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev, 11:2323-34. (PubMed:9308961)
18. Schwab MH et al. (2000) Neuronal basic helix-loop-helix proteins (NEX and BETA2/Neuro D) regulate terminal granule cell differentiation in the hippocampus. J Neurosci, 20:3714-24. (PubMed:10804213)
19. Seo S et al. (2007) Neurogenin and NeuroD direct transcriptional targets and their regulatory enhancers. EMBO J, 26:5093-108. (PubMed:18007592)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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