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Gene Ontology Classifications
neurogenic differentiation 1

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Neurod1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Ahmed M et al. (2012) EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear. Development, 139:1965-77. (PubMed:22513373)
  2. Batsche E et al. (2005) Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription. J Biol Chem, 280:16088-95. (PubMed:15701640)
  3. Chao CS et al. (2007) Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells. Dev Biol, 312:523-32. (PubMed:17988662)
  4. Cho JH et al. (2006) Preferential posterior cerebellum defect in BETA2/NeuroD1 knockout mice is the result of differential expression of BETA2/NeuroD1 along anterior-posterior axis. Dev Biol, 290:125-38. (PubMed:16368089)
  5. Chu K et al. (2005) Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion. Diabetes, 54:1064-73. (PubMed:15793245)
  6. Davies D et al. (2002) Differential expression of alpha3 and alpha6 integrins in the developing mouse inner ear. J Comp Neurol, 445:122-32. (PubMed:11891657)
  7. Inoue T et al. (2002) Math3 and NeuroD regulate amacrine cell fate specification in the retina. Development, 129:831-42. (PubMed:11861467)
  8. Ishii R et al. (2012) Structure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibition. EMBO J, 31:2541-52. (PubMed:22453338)
  9. Jensen J et al. (2000) Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. Diabetes, 49:163-76. (PubMed:10868931)
  10. Kataoka K et al. (2002) MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene. J Biol Chem, 277:49903-10. (PubMed:12368292)
  11. Kim JW et al. (2002) Transactivation of the mouse sulfonylurea receptor I gene by BETA2/NeuroD. Mol Endocrinol, 16:1097-107. (PubMed:11981044)
  12. Kim WY et al. (2001) NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development. Development, 128:417-26. (PubMed:11152640)
  13. Kwon IS et al. (2009) Expression of Disabled 1 suppresses astroglial differentiation in neural stem cells. Mol Cell Neurosci, 40:50-61. (PubMed:18848628)
  14. Lavoie PL et al. (2008) Developmental Dependence on NurRE and EboxNeuro for Expression of Pituitary Proopiomelanocortin. Mol Endocrinol, 22:1647-57. (PubMed:18388149)
  15. Lee D et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell, 2:497-507. (PubMed:18462699)
  16. Lin CH et al. (2004) Regulation of neuroD2 expression in mouse brain. Dev Biol, 265:234-45. (PubMed:14697366)
  17. Liu A et al. (2004) Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity. Mol Cell Biol, 24:4372-83. (PubMed:15121856)
  18. Liu M et al. (2000) Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy [published erratum appears in Proc Natl Acad Sci U S A 2000 May 9;97(10):5679] Proc Natl Acad Sci U S A, 97:865-70. (PubMed:10639171)
  19. Lynn FC et al. (2008) Identification of the bHLH factor Math6 as a novel component of the embryonic pancreas transcriptional network. PLoS ONE, 3:e2430. (PubMed:18560595)
  20. Miyata T et al. (1999) NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus. Genes Dev, 13:1647-52. (PubMed:10398678)
  21. Mutoh H et al. (1998) The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells. Genes Dev, 12:820-30. (PubMed:9512516)
  22. Naya FJ et al. (1997) Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev, 11:2323-34. (PubMed:9308961)
  23. Schwab MH et al. (2000) Neuronal basic helix-loop-helix proteins (NEX and BETA2/Neuro D) regulate terminal granule cell differentiation in the hippocampus. J Neurosci, 20:3714-24. (PubMed:10804213)
  24. Seo S et al. (2007) Neurogenin and NeuroD direct transcriptional targets and their regulatory enhancers. EMBO J, 26:5093-108. (PubMed:18007592)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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