Automated description from the Alliance of Genome Resources (Release 5.1.1)
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and chromatin binding activity. Involved in several processes, including nervous system development; regulation of apoptotic process; and regulation of intestinal epithelial structure maintenance. Acts upstream of or within several processes, including enteroendocrine cell differentiation; negative regulation of receptor signaling pathway via JAK-STAT; and regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Used to study type 1 diabetes mellitus 7. Human ortholog(s) of this gene implicated in glucose intolerance; hyperglycemia; maturity-onset diabetes of the young type 6; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human NEUROD1 (neuronal differentiation 1).